Platelet-derived sTLT-1 is associated with platelet-mediated inflammation in coronary artery disease patients

A Ali, N Mounika, B Nath, E Johny, I Kuladhipati, R Das… - Cytokine, 2024 - Elsevier
The development of coronary artery disease (CAD) depends heavily on platelet activation,
and inflammation plays a major role in all stages of atherosclerosis. Platelet-specific soluble …

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

AA Das, D Chakravarty, D Bhunia, S Ghosh… - Clinical …, 2019 - portlandpress.com
The role of inflammation in all phases of atherosclerotic process is well established and
soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic …

P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: A case control study

L Shen, T Yang, K Xia, Z Yan, J Tan, L Li, Y Qin… - BMC Cardiovascular …, 2020 - Springer
Background Platelet activation plays a crucial role in the pathogenesis of coronary artery
disease (CAD). Platelet P-selectin (CD62P) is a classic platelet activation indicator on the …

Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain

OL Esponda, R Hunter, JRRD Río… - Clinical and Applied …, 2015 - journals.sagepub.com
Objective: Recent studies suggest that the soluble triggering receptor expressed on myeloid
cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 …

High levels of soluble triggering receptor expressed on myeloid cells–like transcript (TLT)-1 are associated with acute respiratory distress syndrome

J Morales-Ortíz, MT Rondina… - Clinical and Applied …, 2018 - journals.sagepub.com
We have previously demonstrated that elevated levels of soluble triggering receptor
expressed on myeloid cells–like transcript 1 (sTLT-1) modulate sepsis-induced inflammation …

Soluble TLT-1 modulates platelet–endothelial cell interactions and actin polymerization

J Morales, K Villa, J Gattis, W Castro… - Blood Coagulation & …, 2010 - journals.lww.com
Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) is a
membrane protein receptor found in α-granules of platelets and megakaryocytes. Upon …

Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) reveals platelet activation in preeclampsia

L He, Y Zhang, C Hou, Z Zhu, Q He, Q Huang, S Ji - Platelets, 2022 - Taylor & Francis
Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) is a
membrane protein receptor found in α-granules of megakaryocytes and platelets. Upon …

Association of decreased serum sTREM-1 level with the severity of coronary artery disease: Inhibitory effect of sTREM-1 on TNF-α-and oxLDL-induced inflammatory …

D Dai, W Xiong, Q Fan, H Wang, Q Chen, W Shen… - Medicine, 2016 - journals.lww.com
Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is closely involved in
autoimmune diseases and inflammatory reactions. We aimed to investigate whether serum …

[HTML][HTML] Human platelets express functional thymic stromal lymphopoietin receptors: a potential role in platelet activation in acute coronary syndrome

B Wang, Y Peng, J Dong, J Lin, C Wu, Y Su… - Cellular Physiology and …, 2013 - karger.com
Background: Thymic stromal lymphopoietin (TSLP) has been shown to be expressed in
various inflammatory tissues, such as human atherosclerotic plaques. Many types of myeloid …

Soluble TREM-like transcript-1 acts as a damage-associated molecular pattern through the TLR4/MD2 pathway contributing to immune dysregulation during sepsis

CM Chang, KH Cheng, TY Wei, MP Lu… - The Journal of …, 2023 - journals.aai.org
Studies have shown that elevated plasma levels of platelet-derived soluble TREM-like
transcript-1 (sTLT-1) are associated with an unfavorable outcome in patients with septic …