The effect of whitlockite as an osteoconductive synthetic bone substitute material in animal bony defect model

JK Ku, I Kim, JH Shim, YH Kim, BH Kim, YK Kim… - Materials, 2022 - mdpi.com
This study aimed to evaluate the biomechanical properties in vitro and the bone
regeneration of whitlockite (WH) compared with hydroxyapatite (HA) or β-tricalcium …

Whitlockite promotes bone healing in rabbit ilium defect model

YZ Jin, GB Zheng, HL Jang, KM Lee, JH Lee - Journal of Medical and …, 2019 - Springer
Purpose Treatment of bone defects commonly employs bone substitutes, like hydroxyapatite
(HAP) and β-tricalcium phosphate (β-TCP) for promoting bone regeneration. However, both …

Effect of Whitlockite as a new bone substitute for bone formation in spinal fusion and ectopic ossification animal model

YZ Jin, GB Zheng, M Cho, JH Lee - Biomaterials Research, 2021 - spj.science.org
Background Bone substrates like hydroxyapatite and tricalcium phosphate have been
widely used for promoting spinal fusion and reducing the complications caused by autograft …

Efficacy for whitlockite for augmenting spinal fusion

SY Kwon, JH Shim, YH Kim, CS Lim, SB An… - International Journal of …, 2021 - mdpi.com
Whitlockite (WH) is the second most abundant inorganic component of human bone,
accounting for approximately 25% of bone tissue. This study investigated the role of WH in …

Synergistic effect of Whitlockite Scaffolds Combined with Alendronate to promote bone regeneration

J Jeong, JH Shim, BM Koo, YB Choy… - Tissue Engineering and …, 2022 - Springer
Background: Due to the increasing aging of society, the number of patients suffering from
senile diseases is increasing. Patients suffering from osteoporosis, which is a representative …

Development and in vivo response of hydroxyapatite/whitlockite from chicken bones as bone substitute using a chitosan membrane for guided bone regeneration

JH Luna-Domínguez, H Téllez-Jiménez… - Ceramics …, 2018 - Elsevier
Biomaterials that meet the requirements to stimulate bone tissue formation play a vital role in
orthopedics and dentistry. In this work, chitosan and a biphasic, non-cytotoxic material …

Whitlockite granules on bone regeneration in defect of rat calvaria

WB Lee, C Wang, JH Lee, KJ Jeong… - ACS Applied Bio …, 2020 - ACS Publications
Whitlockite (WH; Ca18Mg2 (HPO4) 2 (PO4) 12) is a calcium phosphate based ceramic that
contains magnesium ions. As the second most abundant mineral in living bone, WH …

In vitro and in vivo evaluation of biomimetic hydroxyapatite/whitlockite inorganic scaffolds for bone tissue regeneration

Y Pang, D Li, J Zhou, X Liu, M Li, Y Zhang… - Biomedical …, 2022 - iopscience.iop.org
Native bone tissue can be formed by developing collagen fibrils coated with hydroxyapatite
(HA) and whitlockite (WH) nanoparticles after mineralization. WH has attracted much …

Hydrothermal growth of whitlockite coating on β-tricalcium phosphate surfaces for enhancing bone repair potential

X Guo, X Liu, H Gao, X Shi, N Zhao, Y Wang - Journal of materials science …, 2018 - Elsevier
In this study, we developed a simple approach for the controllable growth of whitlockite (WH)
on a β-tricalcium phosphate surface and investigated its cell viability via CCK-8, its live-dead …

Bone regeneration using Wollastonite/β-TCP scaffolds implants in critical bone defect in rat calvaria

GG Dos Santos, IRJB Miguel, AAB Junior… - Biomedical physics …, 2021 - iopscience.iop.org
In order to provide favorable conditions for bone regeneration, a lot of biomaterials have
been developed and evaluated, worldwide. Composite biomaterials have gained notoriety …