Mouse preimplantation embryos consume pyruvate preferentially during the early
developmental stages, before glucose becomes the predominant energy substrate in the …

Although human embryos will develop in vitro for six days or more, little is known about the
effects of the primary nutrients, pyruvate and glucose, on development. Because the nutrient …

Embryos of certain inbred mouse strains, and their F1 hybrids, are able to develop from the 1-
cell to blastocyst stage in simple chemically defined media containing lactate (L), pyruvate …

Preimplantation mouse embryos, cultured in vitro and those freshly flushed from the
reproductive tract, exhibit a switch in energy substrate preference, from pyruvate during the …

Membrane transport of glucose divorced from metabolism, was analysed in 2-cell embryos,
morulae and blastocysts in the preimplantation mouse. A non-metabolizable radiolabelled …

Preimplantation mouse embryos exposed to hyperglycemia, whether in vivo or in vitro,
experience delayed development from the 2-cell to blastocyst stage. By comparing …

The glucose metabolism and embryonic development of rat embryos during organogenesis
was studied using embryo culture. Glucose uptake and embryonic growth and differentiation …

The consumption of pyruvate and glucose, and the production of lactate, by single
preimplantation embryos, was measured using a noninvasive technique. Embryos were …

Preimplantation mouse embryos utilize pyruvate preferentially during the early cleavage
stages before switching to glucose at around the time of compaction. This switch in substrate …

Rate of [14C] glucose uptake by mouse embryos during in vitro culture in media containing
optimal concentrations of lactate and pyruvate increased throughout preimplantation …