[HTML][HTML] Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders

L Lu, Y Xiong, Z Lin, X Chu, AC Panayi, Y Hu… - Frontiers in …, 2022 - frontiersin.org
Extensive research has implicated inflammation and oxidative stress in the development of
multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive …

Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway

Y Deng, Q Xu, T Chen, J Ming, Y Wang, L Mao, J Zhou… - Phytomedicine, 2022 - Elsevier
Background Non-alcoholic steatohepatitis (NASH) has replaced viral hepatitis as the main
driver of the rising morbidity and mortality associated with cirrhosis and liver cancer …

[HTML][HTML] Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

MN Morshed, R Akter, MR Karim, S Iqbal… - Current Issues in …, 2024 - mdpi.com
Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural
abundance that is primarily produced by physicochemical processing, side chain …

[HTML][HTML] Ginsenosides for therapeutically targeting inflammation through modulation of oxidative stress

S Paik, GY Song, EK Jo - International Immunopharmacology, 2023 - Elsevier
Ginsenosides are steroid glycosides derived from ginseng plants such as Panax ginseng,
Panax quinquefolium, and Panax notoginseng. Advances in recent studies have identified …

[HTML][HTML] Kinsenoside alleviates alcoholic liver injury by reducing oxidative stress, inhibiting endoplasmic reticulum stress, and regulating AMPK-dependent autophagy

L Gao, X Chen, Z Fu, J Yin, Y Wang, W Sun… - Frontiers in …, 2022 - frontiersin.org
Background: Anoectochilus roxburghii (Orchidaceae) is a traditional Chinese medicinal herb
with anti-inflammatory, antilipemic, liver protective, immunomodulatory, and other …

[HTML][HTML] Ginsenoside compound K: Insights into recent studies on pharmacokinetics and health-promoting activities

A Sharma, HJ Lee - Biomolecules, 2020 - mdpi.com
Ginseng (Panax ginseng) is an herb popular for its medicinal and health properties.
Compound K (CK) is a secondary ginsenoside biotransformed from major ginsenosides …

Focus on notoginsenoside R1 in metabolism and prevention against human diseases

H Liu, J Yang, W Yang, S Hu, Y Wu… - Drug Design …, 2020 - Taylor & Francis
Abstract Notoginsenoside (NG)-R1 is one of the main bioactive compounds from Panax
notoginseng (PN) root, which is well known in the prescription for mediating the micro …

[PDF][PDF] The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

ESA Arafa, MS Refaey, OAM Abd El-Ghafar… - Heliyon, 2021 - cell.com
The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized
as the target for many potential anti-inflammatory agents. Accumulating evidence indicates …

Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway

R Wang, S Dong, R Xia, M Sun, Y Sun, H Ren… - European Journal of …, 2023 - Elsevier
Ischemia-induced myocardial infarction is regarded as one of the major killers of humans
worldwide. Kinsenoside (KD), a primary active ingredient derived from Anoectochilus …

[HTML][HTML] Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway

JO Lee, E Choi, KK Shin, YH Hong, HG Kim… - Journal of Ginseng …, 2019 - Elsevier
Abstract Background Compound K (CK) is an active metabolite of ginseng saponin,
ginsenoside Rb1, that has been shown to have ameliorative properties in various diseases …