Aims Observational studies indicate that serum urate level is associated with heart failure
(HF). However, whether this association is causal remains controversial, due to confounding …

Background: Although epidemiological studies have reported positive associations between
circulating urate levels and cardiometabolic diseases, causality remains uncertain …

Background The role of urate in cardiovascular diseases (CVDs) has been extensively
investigated in observational studies; however, the extent of any causal effect remains …

Background and aims Observational studies have examined serum urate levels in relation to
coronary heart disease (CHD) and myocardial infarction (MI). Whether these associations …

Background and aims Uric acid, the end-product of purine metabolism within the human
body, has been the subject of studies exploring its potential association with cardiovascular …

Background Mendelian Randomization (MR) studies show conflicting causal associations of
genetically predicted serum urate with cardiovascular risk factors (ie, hypertension, diabetes …

Background Increased circulating plasma urate concentration is associated with an
increased risk of coronary heart disease, but the extent of any causative effect of urate on …

Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …

Aims We aimed to perform a systematic review and meta‐analysis to assess the association
between serum uric acid and incident heart failure (HF)/prognosis of HF patients. Methods …

Background Higher serum uric acid levels are associated with cardiovascular and
neurovascular disease, but whether these relationships are causal is not known. We applied …