The primary goal of the present research investigation is the development and evaluation of
thymoquinone-loaded nanoemulsion (TMQ-NE) for glaucoma therapy. The Box-Behnken …

Glaucoma is one of the most common causes of irreversible vision loss worldwide. The
hydrophilic nature of the anti-glaucoma drug Betaxolol hydrochloride (BH) limits its ocular …

Methods We constructed multifunctional nanoparticles (MMt-BH-HA/CS-ED NPs) by ion
cross-linking-solvent evaporation method. The particle size, zeta potential, encapsulation …

The present study was designed to develop dorzolamide HCl (DRZ) loaded cationic
nanoemulsions (CNEs) for enhanced ocular delivery. CNEs were prepared employing high …

Background To date, the rapid clearance from ocular surface has been a huge obstacle for
using eye drops to treat glaucoma, since it has led to the short preocular residence time and …

Low bioavailability of topically applied drugs remains a significant challenge for long-term
glaucoma therapy. To enhance drug delivery efficiency, we developed dendrimer gel …

Many effective anti-glaucoma drugs available for the treatment of ocular hypertension and
open angle glaucoma are associated with rapid and extensive precorneal loss caused by …

The eye is the specialized part of the body and is comprised of numerous physiological
ocular barriers that limit the drug absorption at the action site. Regardless of various efforts …

The aims of this study were to design and characterize methazolamide (MTZ)-loaded solid
lipid nanoparticles (SLN) with and without modification of low molecular weight chitosan …

Nimodipine (NMD), a calcium channel blocker, has demonstrated benefits in treating
glaucoma. However, its ocular therapeutic application remains limited due to its poor …