Cathepsin C (CatC) is a cysteine dipeptidyl aminopeptidase that activates most of tissue-
degrading elastase-related serine proteases. Thus, CatC appears as a potential therapeutic …

The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for
the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common …

The widespread coronavirus SARS-CoV-2 has already infected over 4 million people
worldwide, with a death toll over 280,000. Current treatment of COVID-19 patients relies …

To discover new drugs to combat COVID-19, an understanding of the molecular basis of
SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of …

Cathepsin C, an important lysosomal cysteine protease, mediates the maturation process of
neutrophil serine proteases, and participates in the inflammation and immune regulation …

Cathepsin C (CatC) is a tetrameric cysteine dipeptidyl aminopeptidase that plays a key role
in activation of pro-inflammatory serine protease zymogens by removal of a N-terminal pro …

Abstract Background SARS-CoV-2, the virus that causes COVID-19, enters the cells through
a mechanism dependent on its binding to angiotensin-converting enzyme 2 (ACE2), a …

Abstract Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-
2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 …

As the death toll from the COVID-19 pandemic caused by SARS-CoV-2 continues to mount
globally, scientists, healthcare agencies, and pharmaceutical companies are trying hard to …

Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …