Roles of TGF-β1 in Viral Infection during Pregnancy: Research Update and Perspectives

QD Trinh, NTK Pham, K Takada, H Ushijima… - International Journal of …, 2023 - mdpi.com
Transforming growth factor-beta 1 (TGF-β1) is a pleiotropic growth factor playing various
roles in the human body including cell growth and development. More functions of TGF-β1 …

TGF-β1 promotes Zika virus infection in immortalized human first-trimester trophoblasts via the Smad pathway

QD Trinh, NTK Pham, K Takada, C Takano… - Cells, 2022 - mdpi.com
The Zika virus (ZIKV) is well known for causing congenital Zika syndrome if the infection
occurs during pregnancy; however, the mechanism by which the virus infects and crosses …

[HTML][HTML] Downregulation of IGF2 expression in third trimester placental tissues from Zika virus infected women in Brazil

AA Suzukawa, C Zanluca, NAN Jorge, L de Noronha… - Journal of Infection, 2020 - Elsevier
Objectives Screening for genes differentially expressed in placental tissues, aiming to
identify transcriptional signatures that may be involved in ZIKV congenital pathogenesis …

The role of TGF-β during pregnancy and pregnancy complications

B Wen, H Liao, W Lin, Z Li, X Ma, Q Xu… - International Journal of …, 2023 - mdpi.com
Transforming growth factor beta (TGF-β), a multifunctional cytokine, is one of the most
important inflammatory cytokines closely related to pregnancy. It plays significant roles in …

Zika virus infection of first trimester trophoblast cells affects cell migration, metabolism and immune homeostasis control

D Vota, M Torti, D Paparini… - Journal of Cellular …, 2021 - Wiley Online Library
Zika virus (ZIKV) re‐emerged after circulating almost undetected for many years and the last
spread in 2015 was the major outbreak reported. ZIKV infection was associated with …

Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain

D Limonta, J Jovel, A Kumar, J Lu, S Hou… - The Journal of …, 2019 - academic.oup.com
Zika virus (ZIKV) is an emerging pathogen that can cause microcephaly and other
neurological defects in developing fetuses. The cellular response to ZIKV in the fetal brain is …

Increased Serum Levels of Growth-Differentiation Factor 3 (GDF3) and Inflammasome-Related Markers in Pregnant Women during Acute Zika Virus Infection

CE de Castro Alves, SA de Melo, J de Melo Silva… - Viruses, 2022 - mdpi.com
The systemic inflammatory response elicited by acute Zika virus (ZIKV) infection during
pregnancy plays a key role in the clinical outcomes in mothers and congenitally infected …

[HTML][HTML] Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 …

C Auriti, DU De Rose, A Santisi, L Martini… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Some maternal infections, contracted before or during pregnancy, can be transmitted to the
fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) …

Role of transforming growth factor-β1 in regulating fetal-maternal immune tolerance in normal and pathological pregnancy

D Yang, F Dai, M Yuan, Y Zheng, S Liu… - Frontiers in …, 2021 - frontiersin.org
Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …

Activation of uterine Smad3 pathway is crucial for embryo implantation

J Li, X Dong, P Yang, S Yang, D Hu, H Zhang… - Current Medical …, 2019 - Springer
Embryo implantation is a complicated physiological process tightly regulated by multiple
biological molecules including growth factors. Transforming growth factor-betas (TGF-βs) …