Roles of TGF-β1 in Viral Infection during Pregnancy: Research Update and Perspectives
Transforming growth factor-beta 1 (TGF-β1) is a pleiotropic growth factor playing various
roles in the human body including cell growth and development. More functions of TGF-β1 …
roles in the human body including cell growth and development. More functions of TGF-β1 …
TGF-β1 promotes Zika virus infection in immortalized human first-trimester trophoblasts via the Smad pathway
The Zika virus (ZIKV) is well known for causing congenital Zika syndrome if the infection
occurs during pregnancy; however, the mechanism by which the virus infects and crosses …
occurs during pregnancy; however, the mechanism by which the virus infects and crosses …
[HTML][HTML] Downregulation of IGF2 expression in third trimester placental tissues from Zika virus infected women in Brazil
AA Suzukawa, C Zanluca, NAN Jorge, L de Noronha… - Journal of Infection, 2020 - Elsevier
Objectives Screening for genes differentially expressed in placental tissues, aiming to
identify transcriptional signatures that may be involved in ZIKV congenital pathogenesis …
identify transcriptional signatures that may be involved in ZIKV congenital pathogenesis …
The role of TGF-β during pregnancy and pregnancy complications
B Wen, H Liao, W Lin, Z Li, X Ma, Q Xu… - International Journal of …, 2023 - mdpi.com
Transforming growth factor beta (TGF-β), a multifunctional cytokine, is one of the most
important inflammatory cytokines closely related to pregnancy. It plays significant roles in …
important inflammatory cytokines closely related to pregnancy. It plays significant roles in …
Zika virus infection of first trimester trophoblast cells affects cell migration, metabolism and immune homeostasis control
D Vota, M Torti, D Paparini… - Journal of Cellular …, 2021 - Wiley Online Library
Zika virus (ZIKV) re‐emerged after circulating almost undetected for many years and the last
spread in 2015 was the major outbreak reported. ZIKV infection was associated with …
spread in 2015 was the major outbreak reported. ZIKV infection was associated with …
Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain
Zika virus (ZIKV) is an emerging pathogen that can cause microcephaly and other
neurological defects in developing fetuses. The cellular response to ZIKV in the fetal brain is …
neurological defects in developing fetuses. The cellular response to ZIKV in the fetal brain is …
Increased Serum Levels of Growth-Differentiation Factor 3 (GDF3) and Inflammasome-Related Markers in Pregnant Women during Acute Zika Virus Infection
CE de Castro Alves, SA de Melo, J de Melo Silva… - Viruses, 2022 - mdpi.com
The systemic inflammatory response elicited by acute Zika virus (ZIKV) infection during
pregnancy plays a key role in the clinical outcomes in mothers and congenitally infected …
pregnancy plays a key role in the clinical outcomes in mothers and congenitally infected …
[HTML][HTML] Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 …
C Auriti, DU De Rose, A Santisi, L Martini… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Some maternal infections, contracted before or during pregnancy, can be transmitted to the
fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) …
fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) …
Role of transforming growth factor-β1 in regulating fetal-maternal immune tolerance in normal and pathological pregnancy
D Yang, F Dai, M Yuan, Y Zheng, S Liu… - Frontiers in …, 2021 - frontiersin.org
Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …
Activation of uterine Smad3 pathway is crucial for embryo implantation
J Li, X Dong, P Yang, S Yang, D Hu, H Zhang… - Current Medical …, 2019 - Springer
Embryo implantation is a complicated physiological process tightly regulated by multiple
biological molecules including growth factors. Transforming growth factor-betas (TGF-βs) …
biological molecules including growth factors. Transforming growth factor-betas (TGF-βs) …