Dynamic changes in gene expression are key factors in the development and activation of
immune cells. RNA metabolism is one of the critical steps for the control of gene expression …

Regulation of messenger RNA (mRNA) decay plays a crucial role in the control of gene
expression. Canonical mRNA decay pathways are initiated by deadenylation and …

The RNase Regnase-1 is a master RNA regulator in macrophages and T cells that degrades
cellular and viral RNA upon NF-κB signaling. The roles of its family members, however …

RNA-binding proteins (RBPs) are central players in post-transcriptional regulation and
immune homeostasis. The ribonuclease and RBP Regnase-1 exerts critical roles in both …

Post-transcriptional regulation is a crucial step for coordinating immune responses. Post-
transcriptional mechanisms exquisitely control inflammation by increasing or decreasing …

The activation of inflammatory cells is controlled at transcriptional and posttranscriptional
levels. Posttranscriptional regulation modifies mRNA stability and translation, allowing for …

Regnase-1 is an RNA-binding protein with ribonuclease activities, and once induced it
controls diverse immune responses by degrading mRNAs that encode inflammatory …

Regnase-1, also known as Zc3h12a or MCPIP1, is responsible for endonucleolytic cleavage
of mRNAs encoding proteins involved in inflammatory responses. Furthermore, Regnase-1 …

Innate immunity is one of the most ancient and conserved aspect of the immune system. It is
responsible for an anti-infective response and has been intrinsically linked to the generation …

ABSTRACT RNA-binding proteins regulate RNA fate and govern post-transcriptional gene
regulation. A new family of RNA-binding proteins is represented by regulatory RNases …