Herein, two series of tryptanthrin derivatives with benzenesulfonamide substituents were
designed and synthesized to discover novel anti-inflammatory agents. The anti-inflammatory …

Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge
(Danshen), displays many bioactivities. However, the activity and underlying mechanism of …

Sixteen novel hesperetin derivatives containing Mannich base moiety were designed and
synthesized and their anti-inflammatory activities were evaluated by inhibiting tumor …

24 derivatives (5a–x) derived from natural pyranochalcones (I and II) were designed and
evaluated for their inhibitory potency on the production of nitric oxide (NO) in LPS-stimulated …

Abstract A series of 1, 3-benzothiazinone derivatives were designed and synthesized for
pharmacological assessments. Among the synthesized 19 compounds, some compounds …

Inflammation is the main cause of several autoimmune diseases, including type I diabetes,
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …

The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate
many physiological processes, including inflammatory responses, morphogenesis, cell …

Inflammatory response plays an important role not only in the normal physiology but also in
the pathology such as cancers. 7b, a novel naphthalimide-based DNA intercalator, has …

Hesperetin has been known to exert several activities such as anti-oxidant, antitumor and
anti-inflammatory. To find hesperetin derivatives showing better activity, sixteen novel …

The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate
many physiological processes, including cell proliferation and differentiation, cell survival …