Paclitaxel (PTX) is an anti-microtubule agent, used for the treatment of various types of
cancers; however, it produces painful neuropathy which limits its use. Many neuroprotective …

Paclitaxel-induced peripheral neuropathic pain (PIPNP) is a major therapy-and dose-limiting
side effect that is extremely laborious to treat. Resveratrol (Res), with a structure name of 3 …

Paclitaxel is an anti-microtubule agent, most widely used chemotherapeutic agent for the
treatment of malignant solid tumors. However, it is associated with some severe side effects …

Paclitaxel (PTX) is an anticancer drug used to treat solid tumors, but one of its common
adverse effects is chemotherapy-induced peripheral neuropathy (CIPN). Currently, there is …

Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel
treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and …

Background Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) is one of the essential
signaling pathways for the development and maintenance of neuropathic pain. Objective To …

Oxaliplatin (OXA) has shown high effectiveness in the treatment of cancers, but its
anticancer clinical effects often induce neurotoxicity leading to neuropathic pain. Oxidative …

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling pain condition which
occurs as a consequence of cancer chemotherapy with anti-cancer agents like paclitaxel …

The widely used cancer treatment, chemotherapy, causes severe long-term neuropathic
pain in 30–40% cases, the condition clinically known as chemotherapy-induced peripheral …

Oxaliplatin is a first-line clinical drug in cancer treatment and its side effects of peripheral
neuropathic pain have also attracted much attention. Neuroinflammation induced by …