Rationale: Pyroptosis is a morphologically and mechanistically distinct form of cell death and
is characterized by GSDMD (gasdermin D) or GSDME (gasdermin E)-mediated necrosis …

Pyroptosis is a form of pro-inflammatory, necrotic cell death mediated by proteins of the
gasdermin family. Various heart diseases, including myocardial ischemia/reperfusion injury …

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …

Background Pyroptosis and oxidative stress play pivotal roles in cardiomyocyte loss after
myocardial infarction. NF-κB is associated with oxidative stress and gasdermin D (GSDMD) …

Background Emodin has recently been reported to have a powerful antiinflammatory effect,
protecting the myocardium against ischemia/reperfusion (I/R) injury. Pyroptosis is a …

Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically
unique form of programmed cell death compared to others, such as apoptosis and …

Acute occlusion of a coronary artery can result in myocardial infarction—a leading cause of
premature death. Prompt restoration of blood flow to the myocardium can prevent excessive …

While ischemia itself can kill heart muscle, much of the infarction after a transient period of
coronary artery occlusion has been found to result from injury during reperfusion. Here we …

Cardiovascular disease (CVD) is a common disease that poses a huge threat to human
health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative …

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …