Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been
suggested that in the progressive late phase, inflammatory lesion activity declines. We …

Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

T cells are considered pivotal in the pathology of multiple sclerosis (MS), but their function
and antigen specificity are unknown. To unravel the role of T cells in MS pathology, we …

Using monoclonal antibodies in combination with the PAP technique, total (T11+) T cells,
helper-inducer (T4+) T cells, suppressor-cytotoxic (T8+) T cells and Ia+ cells (macrophages …

Objective In multiple sclerosis (MS), central nervous system (CNS), cerebrospinal fluid
(CSF), and blood display TCR clonal expansions of CD 8+ T cells. These clones have been …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). In
MS patients being treated with anti–T11, a murine monoclonal antibody which recognizes …

Although T cells play a pathogenetic role in MS, specific disease-inducing T cells have not
been identified. T cells can be labeled and traced in adoptively transferred experimental …

Clonally expanded CD8+ T lymphocytes are present in multiple sclerosis lesions, as well as
in the cerebrospinal fluid of patients with multiple sclerosis. In experimental autoimmune …

Objective CD4 T‐cell–dependent macrophage activation directed against a myelin or
oligodendrocyte antigen is generally thought to be the mechanism causing myelin …

Background Macrophages play a dual role in multiple sclerosis (MS) pathology. They can
exert neuroprotective and growth promoting effects but also contribute to tissue damage by …