Autophagy is a highly coordinated process that is controlled at several levels including
transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear …

Chaperone-mediated autophagy (CMA) is a selective degradative process for cytosolic
proteins that contributes to the maintenance of proteostasis. The signaling mechanisms that …

In response to different environmental stresses, eIF2α phosphorylation represses global
translation coincident with preferential translation of ATF4, a master regulator controlling the …

Significant evidences indicate that reactive oxygen species (ROS) can induce
macroautophagy/autophagy under both physiological and pathological conditions. Although …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

The selective autophagy receptor p62/sequestosome 1 (SQSTM1) interacts directly with LC3
and is involved in oxidative stress signaling in two ways in mammals. First, p62 is …

Macroautophagy is a major intracellular degradation process recognized as playing a
central role in cell survival and longevity. This multistep process is extensively regulated at …

The mechanisms of the control and activity of the autophagy-lysosomal protein degradation
machinery are emerging as an important theme for neurodevelopment and …

The ubiquitin-proteasome system and autophagy are crucially important for proteostasis in
cells. These pathways are interdependent, and dysfunction in either pathway causes …

Macroautophagy/autophagy failure with the accumulation of autophagosomes is an early
neuropathological feature of Alzheimer disease (AD) that directly affects amyloid beta (Aβ) …