Satellite cell-mediated myonuclear accretion is thought to be required for skeletal muscle
fiber hypertrophy, and even drive hypertrophy by preceding growth. Recent studies in …

Myofiber size is dynamically regulated, increasing and decreasing depending on muscle
use. Hypertrophy is defined by increases in myofiber cross-sectional area and mass as well …

Recent loss-of-function studies show that satellite cell depletion does not promote
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …

Abstract Background Satellite cells (SCs) are required for muscle repair following injury and
are involved in muscle remodeling upon muscular contractions. Exercise stimulates SC …

The largest mammalian cells are the muscle fibers, and they have multiple nuclei to support
their large cytoplasmic volumes. During hypertrophic growth, new myonuclei are recruited …

Skeletal muscle is composed of post-mitotic myofibers that form a syncytium containing
hundreds of myonuclei. Using a progressive exercise training model in the mouse and …

Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

Resident muscle stem cells, known as satellite cells, are thought to be the main mediators of
skeletal muscle plasticity. Satellite cells are activated, replicate, and fuse into existing …

The “canonical” function of Pax7+ muscle stem cells (satellite cells) during hypertrophic
growth of adult muscle fibers is myonuclear donation via fusion to support increased …

An important unresolved question in skeletal muscle plasticity is whether satellite cells are
necessary for muscle fiber hypertrophy. To address this issue, a novel mouse strain (Pax7 …