Mimics of host defense proteins; strategies for translation to therapeutic applications
RW Scott, GN Tew - Current Topics in Medicinal Chemistry, 2017 - ingentaconnect.com
New infection treatments are urgently needed to combat the rising threat of multi-drug
resistant bacteria. Despite early clinical set-backs attention has re-focused on host defense …
resistant bacteria. Despite early clinical set-backs attention has re-focused on host defense …
Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications
ON Silva, KCL Mulder, AEAD Barbosa… - Frontiers in …, 2011 - frontiersin.org
In the last few years, the number of bacteria with enhanced resistance to conventional
antibiotics has dramatically increased. Most of such bacteria belong to regular microbial …
antibiotics has dramatically increased. Most of such bacteria belong to regular microbial …
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity
N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2023 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …
Therapeutic potential of host defense peptides in antibiotic-resistant infections
NJ Afacan, A TY Yeung, OM Pena… - Current …, 2012 - ingentaconnect.com
The emergence of infections caused by multi-drug resistant (MDR) pathogens pose a major
burden to modern healthcare. Exacerbating this issue is the substantial decline in …
burden to modern healthcare. Exacerbating this issue is the substantial decline in …
Emerging themes and therapeutic prospects for anti-infective peptides
NY Yount, MR Yeaman - Annual review of pharmacology and …, 2012 - annualreviews.org
Pathogens resistant to most conventional anti-infectives are a harbinger of the need to
discover and develop novel anti-infective agents and strategies. Endogenous host defense …
discover and develop novel anti-infective agents and strategies. Endogenous host defense …
Going beyond host defence peptides: horizons of chemically engineered peptides for multidrug-resistant bacteria
B Cavallazzi Sebold, J Li, G Ni, Q Fu, H Li, X Liu… - BioDrugs, 2023 - Springer
Multidrug-resistant (MDR) bacteria are considered a health threat worldwide, and this
problem is set to increase over the decades. The ESKAPE, a group of six pathogens …
problem is set to increase over the decades. The ESKAPE, a group of six pathogens …
Strategies in translating the therapeutic potentials of host defense peptides
The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …
Perspectives for clinical use of engineered human host defense antimicrobial peptides
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …
death worldwide. The emergence of drug-resistance mechanisms, especially among …
Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity
Antimicrobial host defense peptides (HDPs) are a critical component of the innate immunity
with microbicidal, endotoxin-neutralizing, and immunostimulatory properties. HDPs kill …
with microbicidal, endotoxin-neutralizing, and immunostimulatory properties. HDPs kill …
Structure-activity relationships of multifunctional host defence peptides
J Kindrachuk, S Napper - Mini reviews in medicinal chemistry, 2010 - ingentaconnect.com
Host defence peptides (HDPs) are multi-functional inducers and effectors of host immunity.
Through their direct antimicrobial activity HDPs have for been successfully utilized for many …
Through their direct antimicrobial activity HDPs have for been successfully utilized for many …