The endocrine system, consisting of the hypothalamus, pituitary, endocrine glands, and
hormones, plays a critical role in hormone metabolic interactions. The complexity of the …

Decades of research have shown that conventional two-dimensional cell line-based in vitro
models do not fully recapitulate the complexity of tissue composition or disease …

Generation of a variety of organs and tissues from human pluripotent stem cells (hPSCs) has
been attempted in vitro. We here present a simple and efficient method for induction of …

Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

The pituitary is the master endocrine gland regulating key physiological processes,
including body growth, metabolism, sexual maturation, reproduction, and stress response …

The pituitary is the master endocrine gland, harboring stem cells of which the phenotype and
role remain poorly characterized. Here, we established organoids from mouse pituitary with …

In the last decade, organoid research has entered a golden era, signifying a pivotal shift in
the biomedical landscape. The year 2023 marked a milestone with the publication of …

The past decade has witnessed the development of a powerful new model to study human
disease: stem cell–derived organoids. These are 3-dimensional structures recapitulating the …

The in-vivo non-human primate animal and in-vitro cell disease models play a crucial part in
the study of the mechanisms underlying the occurrence and development of pancreatic …

Abstract 3D culture has allowed the initiation and expansion of organ-like structures, called
organoids, from either tissue-resident adult stem cells or pluripotent stem cells. Today …