Oxygen-derived free radicals and related oxidants are ubiquitous and short-lived
intermediates formed in aerobic organisms throughout life. These reactive species …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …

The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

Peroxynitrite is formed by the very fast reaction of nitric oxide and superoxide radicals, a
reaction that kinetically competes with other routes that chemically consume or physically …

In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine
nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide …

The discovery that nitric oxide (NO) reacts with Superoxide (O2−) forming peroxynitrite
(ONOO−)(1) and the proof that this reaction occurs in vivo (2, 3) holds enormous implications …

Nitric oxide participates in a wide array of physiological processes, ranging from
neurotransmission to precursor of cytotoxic effector molecules of the immune system …

The reactive oxygen and nitrogen species Superoxide ion, nitric oxide, nitrogen dioxide and
peroxynitrite ion all react with biological target molecules. Some of these interactions are …

The discovery that nitric oxide is produced in our bodies has sparked one of the greatest
scientific bonanzas of the last decade. This free radical is relatively benign, binds avidly to …