A range of antibiotics, in addition to those that target folate metabolism, have demonstrated
antimalarial activity. They include those belonging to the lincosamides, tetracyclines and …

The impact of selected antibiotics on combating malaria infections was discovered in the mid
of last century. Only recently, studies on their modes of action in malaria parasites have …

With first indications of resistance against artemisinin compounds, the development of novel
alternative antimalarials remains an urgent need. One candidate is fosmidomycin (Fos), a …

The inhibition or disruption of folate metabolism remains an attractive target for the discovery
of new antimalarial drugs. The importance of this pathway was proved in the 1940s with the …

Several classes of antibiotics exert antimalarial activity. The mechanisms of action of
antibiotics against malaria parasites have been unclear, and prior studies have led to …

With the emergence of Plasmodium falciparum infections exhibiting increased parasite
clearance times in response to treatment with artemisinin-based combination therapies, the …

The evolution of resistance by the malaria parasite to artemisinin, the key component of the
combination therapy strategies that are at the core of current antimalarial treatments, calls for …

Chemotherapy remains the most important means of controlling malaria, one of the
deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been …

We have synthesized new derivatives of the macrolide antibiotics erythromycin and
azithromycin. Novel deoxysugar moieties were attached to these standard antibiotics by …

Antifolates targeting dihydrofolate reductase (DHFR) are antimalarial compounds that have
long been used for malaria treatment and chemoprevention (inhibition of infection from …