A systems biology approach and in vitro experiment indicated Rapamycin targets key cancer and cell cycle‐related genes and miRNAs in triple‐negative breast …
An anticancer drug known as Rapamycin acts by inhibiting the mammalian target of the
Rapamycin pathway. This agent has recently been investigated for its potential therapeutic …
Rapamycin pathway. This agent has recently been investigated for its potential therapeutic …
Identification of miR‐3182 and miR‐3143 target genes involved in the cell cycle as a novel approach in TNBC treatment: a systems biology approach
Y Khazaei‐Poul, SA Mirmotalebisohi… - Chemical Biology & …, 2023 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor
prognosis, lacking therapeutic targets. miRNAs play crucial roles in TNBC through …
prognosis, lacking therapeutic targets. miRNAs play crucial roles in TNBC through …
Wnt pathway targeting reduces triple‐negative breast cancer aggressiveness through miRNA regulation in vitro and in vivo
S Mohammadi‐Yeganeh, V Hosseini… - Journal of Cellular …, 2019 - Wiley Online Library
Triple‐negative breast cancer, devoid of estrogen (ER), progesterone (PR), and human
epidermal growth factor receptor 2 (HER‐2) expression, is deprived of commonly used …
epidermal growth factor receptor 2 (HER‐2) expression, is deprived of commonly used …
[HTML][HTML] MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells
SKBR3-cells, characterized by ERBB2/RARA co-amplification, represent a subgroup of
HER2+ breast-cancers sensitive to all-trans retinoic acid (ATRA) and Lapatinib. In this …
HER2+ breast-cancers sensitive to all-trans retinoic acid (ATRA) and Lapatinib. In this …
Comprehensive integrated analysis of gene expression datasets identifies key anti-cancer targets in different stages of breast cancer
MT Gong, SD Ye, WW Lv, K He… - Experimental and …, 2018 - spandidos-publications.com
Breast cancer is one of the primary threats to women's health worldwide. However, the
molecular mechanisms underlying the development of breast cancer remain to be fully …
molecular mechanisms underlying the development of breast cancer remain to be fully …
Kinome-wide siRNA screening identifies Src-enhanced resistance of chemotherapeutic drugs in triple-negative breast cancer cells
YDT Tzeng, PF Liu, JY Li, LF Liu, SY Kuo… - Frontiers in …, 2018 - frontiersin.org
Background: Chemotherapy is the main treatment for triple-negative breast cancer (TNBC),
which lack molecular markers for diagnosis and therapy. Cancer cells activate …
which lack molecular markers for diagnosis and therapy. Cancer cells activate …
Identification of chemoresistance associated key genes-miRNAs-TFs in docetaxel resistant breast cancer by bioinformatics analysis
The present study aimed to identify the differentially expressed genes (DEGs) and enriched
pathways in docetaxel (DTX) resistant breast cancer cell lines by bioinformatics analysis …
pathways in docetaxel (DTX) resistant breast cancer cell lines by bioinformatics analysis …
Model-based integration analysis revealed presence of novel prognostic miRNA targets and important cancer driver genes in triple-negative breast cancers
Background: miRNAs (microRNAs) play a key role in triple-negative breast cancer (TNBC)
progression, and its heterogeneity at the expression, pathological and clinical levels …
progression, and its heterogeneity at the expression, pathological and clinical levels …
Identification of chemoresistance-associated microRNAs and hub genes in breast cancer using bioinformatics analysis
M Wu, Y Zhao, N Peng, Z Tao, B Chen - Investigational New Drugs, 2021 - Springer
Breast cancer threatens women's health. Although there are a lot of methods to treat breast
cancer, chemotherapy resistance still hinders the effectiveness of treatment. This study …
cancer, chemotherapy resistance still hinders the effectiveness of treatment. This study …
Transcriptomic analysis revealed potential regulatory biomarkers and repurposable drugs for breast cancer treatment
M Shornale Akter, MH Uddin, S Atikur Rahman… - Cancer …, 2024 - Wiley Online Library
Breast cancer (BC) is the most widespread cancer worldwide. Over 2 million new cases of
BC were identified in 2020 alone. Despite previous studies, the lack of specific biomarkers …
BC were identified in 2020 alone. Despite previous studies, the lack of specific biomarkers …