A systems biology approach and in vitro experiment indicated Rapamycin targets key cancer and cell cycle‐related genes and miRNAs in triple‐negative breast …

A Tafti, S Shojaei, H Zali, S Karima… - Molecular …, 2023 - Wiley Online Library
An anticancer drug known as Rapamycin acts by inhibiting the mammalian target of the
Rapamycin pathway. This agent has recently been investigated for its potential therapeutic …

Identification of miR‐3182 and miR‐3143 target genes involved in the cell cycle as a novel approach in TNBC treatment: a systems biology approach

Y Khazaei‐Poul, SA Mirmotalebisohi… - Chemical Biology & …, 2023 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor
prognosis, lacking therapeutic targets. miRNAs play crucial roles in TNBC through …

Wnt pathway targeting reduces triple‐negative breast cancer aggressiveness through miRNA regulation in vitro and in vivo

S Mohammadi‐Yeganeh, V Hosseini… - Journal of Cellular …, 2019 - Wiley Online Library
Triple‐negative breast cancer, devoid of estrogen (ER), progesterone (PR), and human
epidermal growth factor receptor 2 (HER‐2) expression, is deprived of commonly used …

[HTML][HTML] MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells

JN Fisher, M Terao, M Fratelli, M Kurosaki, G Paroni… - Oncotarget, 2015 - ncbi.nlm.nih.gov
SKBR3-cells, characterized by ERBB2/RARA co-amplification, represent a subgroup of
HER2+ breast-cancers sensitive to all-trans retinoic acid (ATRA) and Lapatinib. In this …

Comprehensive integrated analysis of gene expression datasets identifies key anti-cancer targets in different stages of breast cancer

MT Gong, SD Ye, WW Lv, K He… - Experimental and …, 2018 - spandidos-publications.com
Breast cancer is one of the primary threats to women's health worldwide. However, the
molecular mechanisms underlying the development of breast cancer remain to be fully …

Kinome-wide siRNA screening identifies Src-enhanced resistance of chemotherapeutic drugs in triple-negative breast cancer cells

YDT Tzeng, PF Liu, JY Li, LF Liu, SY Kuo… - Frontiers in …, 2018 - frontiersin.org
Background: Chemotherapy is the main treatment for triple-negative breast cancer (TNBC),
which lack molecular markers for diagnosis and therapy. Cancer cells activate …

Identification of chemoresistance associated key genes-miRNAs-TFs in docetaxel resistant breast cancer by bioinformatics analysis

B Raju, G Narendra, H Verma, O Silakari - 3 Biotech, 2024 - Springer
The present study aimed to identify the differentially expressed genes (DEGs) and enriched
pathways in docetaxel (DTX) resistant breast cancer cell lines by bioinformatics analysis …

Model-based integration analysis revealed presence of novel prognostic miRNA targets and important cancer driver genes in triple-negative breast cancers

M Zaka, CW Sutton, Y Peng, S Konur - Cancers, 2020 - mdpi.com
Background: miRNAs (microRNAs) play a key role in triple-negative breast cancer (TNBC)
progression, and its heterogeneity at the expression, pathological and clinical levels …

Identification of chemoresistance-associated microRNAs and hub genes in breast cancer using bioinformatics analysis

M Wu, Y Zhao, N Peng, Z Tao, B Chen - Investigational New Drugs, 2021 - Springer
Breast cancer threatens women's health. Although there are a lot of methods to treat breast
cancer, chemotherapy resistance still hinders the effectiveness of treatment. This study …

Transcriptomic analysis revealed potential regulatory biomarkers and repurposable drugs for breast cancer treatment

M Shornale Akter, MH Uddin, S Atikur Rahman… - Cancer …, 2024 - Wiley Online Library
Breast cancer (BC) is the most widespread cancer worldwide. Over 2 million new cases of
BC were identified in 2020 alone. Despite previous studies, the lack of specific biomarkers …