A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses
The engineered outer domain germline targeting version 8 (eOD-GT8) 60-mer nanoparticle
was designed to prime VRC01-class HIV-specific B cells that would need to be matured …
was designed to prime VRC01-class HIV-specific B cells that would need to be matured …
Rational HIV immunogen design to target specific germline B cell receptors
Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Traditional vaccine development to prevent some of the worst current pandemic diseases
has been unsuccessful so far. Germline-targeting immunogens have potential to prime …
has been unsuccessful so far. Germline-targeting immunogens have potential to prime …
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
A major obstacle to a broadly neutralizing antibody (bnAb)–based HIV vaccine is the
activation of appropriate B cell precursors. Germline-targeting immunogens must be capable …
activation of appropriate B cell precursors. Germline-targeting immunogens must be capable …
[PDF][PDF] Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization
C Havenar-Daughton, DG Carnathan, AV Boopathy… - Cell reports, 2019 - cell.com
The first immunization in a protein prime-boost vaccination is likely to be critical for how the
immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes …
immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes …
Adjuvanting a simian immunodeficiency virus vaccine with toll-like receptor ligands encapsulated in nanoparticles induces persistent antibody responses and …
SP Kasturi, PA Kozlowski, HI Nakaya… - Journal of …, 2017 - Am Soc Microbiol
Our previous work has shown that antigens adjuvanted with ligands specific for Toll-like
receptor 4 (TLR4) and TLR7/8 encapsulated in poly (lactic-co-glycolic) acid (PLGA)-based …
receptor 4 (TLR4) and TLR7/8 encapsulated in poly (lactic-co-glycolic) acid (PLGA)-based …
[HTML][HTML] Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations
JT Martin, CA Cottrell, A Antanasijevic, DG Carnathan… - npj Vaccines, 2020 - nature.com
Following immunization, high-affinity antibody responses develop within germinal centers
(GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and …
(GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and …
Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice
CA Cottrell, X Hu, JH Lee, P Skog, S Luo… - Science Translational …, 2024 - science.org
A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs).
Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with …
Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with …
[HTML][HTML] A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204)
GJ Churchyard, C Morgan, E Adams, J Hural… - PloS one, 2011 - journals.plos.org
Background The safety and immunogenicity of a vaccine regimen consisting of a 6-plasmid
HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a recombinant …
HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a recombinant …
[HTML][HTML] Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates
Peptide immunogens provide an approach to focus antibody responses to specific
neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However …
neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However …