Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
The functional maturation and preservation of hepatic cells derived from human induced
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …
3D bioprinting of liver spheroids derived from human induced pluripotent stem cells sustain liver function and viability in vitro
E Goulart, LC de Caires-Junior, KA Telles-Silva… - …, 2019 - iopscience.iop.org
The liver is responsible for many metabolic, endocrine and exocrine functions.
Approximately 2 million deaths per year are associated with liver failure. Modern 3D …
Approximately 2 million deaths per year are associated with liver failure. Modern 3D …
Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D
A Faulkner-Jones, C Fyfe, DJ Cornelissen… - …, 2015 - iopscience.iop.org
We report the first investigation into the bioprinting of human induced pluripotent stem cells
(hiPSCs), their response to a valve-based printing process as well as their post-printing …
(hiPSCs), their response to a valve-based printing process as well as their post-printing …
Generation of multi-cellular human liver organoids from pluripotent stem cells
WL Thompson, T Takebe - Methods in cell biology, 2020 - Elsevier
A growing number of in vitro hepatic models exist to study human genetics, liver biology,
disease modeling and drug development and range from 2D hepatocytes to 3D multi …
disease modeling and drug development and range from 2D hepatocytes to 3D multi …
In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system
Liver organoids derived from human pluripotent stem cells (PSCs) represent a new type of in
vitro liver model for understanding organ development, disease mechanism and drug …
vitro liver model for understanding organ development, disease mechanism and drug …
[HTML][HTML] Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery
H Kizawa, E Nagao, M Shimamura, G Zhang… - … and biophysics reports, 2017 - Elsevier
The liver plays a central role in metabolism. Although many studies have described in vitro
liver models for drug discovery, to date, no model has been described that can stably …
liver models for drug discovery, to date, no model has been described that can stably …
[HTML][HTML] Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture
Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce
the demand for a dwindling number of primary cells used in applications ranging from …
the demand for a dwindling number of primary cells used in applications ranging from …
The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets
Y Nagamoto, K Tashiro, K Takayama, K Ohashi… - Biomaterials, 2012 - Elsevier
Hepatocyte-like cells differentiated from human embryonic stem cells (hESCs) or human
induced pluripotent stem cells (hiPSCs) are known to be a useful cell source for drug …
induced pluripotent stem cells (hiPSCs) are known to be a useful cell source for drug …
[HTML][HTML] Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities
F Salaris, A Rosa - Brain research, 2019 - Elsevier
Abstract Three-dimensional (3D) printing of biological material, or 3D bioprinting, is a rapidly
expanding field with interesting applications in tissue engineering and regenerative …
expanding field with interesting applications in tissue engineering and regenerative …
Functional maturation of induced pluripotent stem cell hepatocytes in extracellular matrix—a comparative analysis of bioartificial liver microenvironments
Induced pluripotent stem cells (iPSCs) are new diagnostic and potentially therapeutic tools
to model disease and assess the toxicity of pharmaceutical medications. A common …
to model disease and assess the toxicity of pharmaceutical medications. A common …