Rationale: Although airway microbiota composition correlates with clinical measures in non–
cystic fibrosis bronchiectasis, these data are unlikely to provide useful prognostic information …

Rationale: Characterization of bacterial populations in infectious respiratory diseases will
provide improved understanding of the relationship between the lung microbiota, disease …

Rationale Despite the potentially important roles for infection in adult non-cystic fibrosis (CF)
bronchiectasis disease progression, the bacterial species present in the lower airways of …

A diverse microbiota exists within the airways of individuals with non-cystic fibrosis
bronchiectasis (nCFB). How the lung microbiome evolves over time, and whether changes …

Background Infection is a key component of bronchiectasis pathophysiology.
Characterisation of the microbiome offers a higher degree of sensitivity and resolution than …

Background Molecular-based diagnostic techniques can compensate for the inherent
limitations of culture-based microbiology and provide a more comprehensive description of …

Background Chronic airway infection contributes to the underlying pathogenesis of non-
cystic fibrosis bronchiectasis (NCFBr). In contrast to other chronic airway infections …

Background Bronchiectasis is accompanied by chronic bronchial infection that may drive
disease progression. However, the evidence base for antibiotic therapy is limited. DNA …

Rationale: Although inflammation and infection are key disease drivers in bronchiectasis,
few studies have integrated host inflammatory and microbiome data to guide precision …

Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …