Advances in physiological functions and mechanisms of (−)-epicatechin

Z Qu, A Liu, P Li, C Liu, W Xiao, J Huang… - Critical reviews in …, 2021 - Taylor & Francis
Epicatechin (EC) is a flavanol easily obtained through the diet and is present in tea, cocoa,
vegetables, fruits, and cereals. Recent studies have shown that EC protects human health …

Biological activities of (−)-epicatechin and (−)-epicatechin-containing foods: Focus on cardiovascular and neuropsychological health

I Bernatova - Biotechnology Advances, 2018 - Elsevier
Recent studies have suggested that certain (−)-epicatechin-containing foods have a blood
pressure-lowering capacity. The mechanisms underlying (−)-epicatechin action may help …

(‐)‐Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high‐fat diet

H Cheng, N Xu, W Zhao, J Su, M Liang… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope (‐)‐Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea, and a
variety of other plant foods. In this study, effects of EC on blood lipids and hepatic steatosis …

Structures of (−)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (−)-epicatechin: differences between human and rat

M Natsume, N Osakabe, M Oyama, M Sasaki… - Free Radical Biology …, 2003 - Elsevier
(−)-Epicatechin is one of the most potent antioxidants present in the human diet. Particularly
high levels are found in black tea, apples, and chocolate. High intake of catechins has been …

Elucidation of (−)-epicatechin metabolites after ingestion of chocolate by healthy humans

L Actis-Goretta, A Lévèques, F Giuffrida… - Free Radical Biology …, 2012 - Elsevier
After absorption in the gastrointestinal tract,(−)-epicatechin is extensively transformed into
various conjugated metabolites. These metabolites, chemically different from the aglycone …

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives

JI Ottaviani, G Borges, TY Momma, JPE Spencer… - Scientific reports, 2016 - nature.com
Diet is a major life style factor affecting human health, thus emphasizing the need for
evidence-based dietary guidelines for primary disease prevention. While current …

Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers

S Baba, N Osakabe, A Yasuda, M Natsume… - Free radical …, 2000 - Taylor & Francis
We evaluated the levels of (-)-epicatechin (EC) and its metabolites in plasma and urine after
intake of chocolate or cocoa by male volunteers. EC metabolites were analyzed by HPLC …

(–)-Epicatechin in the control of glucose homeostasis: Involvement of redox-regulated mechanisms

E Cremonini, CG Fraga, PI Oteiza - Free Radical Biology and Medicine, 2019 - Elsevier
Emerging evidence supports a beneficial action of the flavan-3-ol (–)-epicatechin (EC) on
insulin sensitivity and potential impact on the development/progression of type 2 diabetes …

Rapid liquid chromatography tandem mass spectrometry assay to quantify plasma (−)-epicatechin metabolites after ingestion of a standard portion of cocoa beverage …

E Roura, C Andrés-Lacueva, O Jáuregui… - Journal of agricultural …, 2005 - ACS Publications
A rapid liquid chromatography electrospray ionization tandem mass spectrometry with
negative ion detection method was developed and validated to determine cocoa flavonoid …

Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings

G Borges, JI Ottaviani, JJJ van der Hooft… - Molecular Aspects of …, 2018 - Elsevier
This paper reviews pioneering human studies, their limitations and recent investigations on
the absorption, metabolism, distribution and excretion (aka bioavailability) of (–)-epicatechin …