Human leukocyte antigens (HLA) are cell-surface proteins that present peptides to T cells.
These peptides are bound within the peptide binding cleft of HLA, and together as a …

Previous studies have attempted to define human leukocyte antigen (HLA) class II
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …

Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …

Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …

Abstract MHC class I molecules (HLA-I in humans) present peptides derived from
endogenous proteins to CTLs. Whereas the peptide-binding specificities of HLA-A and-B …

Publisher Summary This chapter integrates the two different areas of extensive human
leukocyte antigen (HLA) research: first, the association between peptides and HLA class II …

The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles
both in the innate and adaptive immune system. Starting already during embryogenesis and …

Peptide binding to class I major histocompatibility complex (MHCI) molecules is a key step in
the immune response and the structural details of this interaction are of importance in the …

Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human
genome. Almost all polymorphic residues are located in the peptide-binding groove …

HLA class I–binding predictions are widely used to identify candidate peptide targets of
human CD8+ T cell responses. Many such approaches focus exclusively on a limited range …