The pockets guide to HLA class I molecules
Human leukocyte antigens (HLA) are cell-surface proteins that present peptides to T cells.
These peptides are bound within the peptide binding cleft of HLA, and together as a …
These peptides are bound within the peptide binding cleft of HLA, and together as a …
HLA class I allele promiscuity revisited
X Rao, I Hoof, AICA Fontaine Costa, D van Baarle… - Immunogenetics, 2011 - Springer
The peptide repertoire presented on human leukocyte antigen (HLA) class I molecules is
largely determined by the structure of the peptide binding groove. It is expected that the …
largely determined by the structure of the peptide binding groove. It is expected that the …
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across …
Previous studies have attempted to define human leukocyte antigen (HLA) class II
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …
A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
Predicting antigen presentation—what could we learn from a million peptides?
D Gfeller, M Bassani-Sternberg - Frontiers in immunology, 2018 - frontiersin.org
Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …
For this reason, important efforts have been made to predict which peptides are more likely …
[HTML][HTML] Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule
M Rasmussen, M Harndahl, A Stryhn… - The Journal of …, 2014 - journals.aai.org
Abstract MHC class I molecules (HLA-I in humans) present peptides derived from
endogenous proteins to CTLs. Whereas the peptide-binding specificities of HLA-A and-B …
endogenous proteins to CTLs. Whereas the peptide-binding specificities of HLA-A and-B …
HLA class II peptide binding specificity and autoimmunity
J Hammer, T Sturniolo, F Sinigagua - Advances in Immunology, 1997 - Elsevier
Publisher Summary This chapter integrates the two different areas of extensive human
leukocyte antigen (HLA) research: first, the association between peptides and HLA class II …
leukocyte antigen (HLA) research: first, the association between peptides and HLA class II …
Unveiling the peptide motifs of HLA-C and HLA-G from naturally presented peptides and generation of binding prediction matrices
M Di Marco, H Schuster, L Backert… - The Journal of …, 2017 - journals.aai.org
The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles
both in the innate and adaptive immune system. Starting already during embryogenesis and …
both in the innate and adaptive immune system. Starting already during embryogenesis and …
Structural prediction of peptides binding to MHC class I molecules
HH Bui, AJ Schiewe, H von Grafenstein… - Proteins: Structure …, 2006 - Wiley Online Library
Peptide binding to class I major histocompatibility complex (MHCI) molecules is a key step in
the immune response and the structural details of this interaction are of importance in the …
the immune response and the structural details of this interaction are of importance in the …
Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?
HWM van Deutekom, C Keşmir - Immunogenetics, 2015 - Springer
Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human
genome. Almost all polymorphic residues are located in the peptide-binding groove …
genome. Almost all polymorphic residues are located in the peptide-binding groove …