Synthesis, in-vitro and in-silico antibacterial and computational studies of selected thiosemicarbazone-benzaldehyde derivatives as potential antibiotics

AA Olanrewaju, DG Oke, DO Adekunle, OA Adeleke… - SN Applied …, 2023 - Springer
Three new Schiff bases,(Z)-2-(4-(dimethylamino) benzylidene)-N-
methylhydrazinecarbothioamide (PDM),(Z)-2-(2-hydroxy-5-nitrobenzylidene)-N …

Synthesis, characterization, antibacterial activity of thiosemicarbazones derivatives and their computational approaches: Quantum calculation, molecular docking …

M Alam, MN Abser, A Kumer, MMH Bhuiyan, P Akter… - Heliyon, 2023 - cell.com
The thiosemicarbazones and their derivatives have been recognized as antimicrobial
agents against human pathogenic bacteria and fungi. Regarding these prospective, this …

Synthesis, geometrical, spectral and anti bacterial studies of 4-hydroxy-3-methoxybenzaldehyde thiosemicarbazone by experimental and theoretical investigations

J Swaminathan, P Anbusrinivasan… - Computational and …, 2023 - Elsevier
Abstract Vanillin thiosemicarbazone or 4-hydroxy-3-methoxybenzaldehyde
thiosemicarbazone (HMBT) was synthesized using 4-hydroxy-3-methoxybenzaldehyde …

Design, spectral, antibacterial and in-silico studies of new thiosemicarbazones and semicarbazones derived from symmetrical chalcones

N Sharma, N Dhingra, HL Singh - Journal of Molecular Structure, 2024 - Elsevier
A series of new Schiff bases of semicarbazones and thiosemicarbazones have been derived
from the condensation of symmetrical chalcones with semicarbazide and thiosemicarbazide …

Antioxidant, antimicrobial, and theoretical studies of the thiosemicarbazone derivative Schiff base 2-(2-imino-1-methylimidazolidin-4-ylidene) …

AA Al-Amiery, YK Al-Majedy, HH Ibrahim… - Organic and medicinal …, 2012 - Springer
Background Adverse antimicrobial activities of thiosemicarbazone (TSC) and Schiff base
derivatives have widely been studied by using different kinds of microbes, in addition …

[HTML][HTML] Synthesis, molecular structure and antibacterial activity of benzylmethyl-4-methyl-3-thiosemicarbazone

JA Mbah, GA Ayimele, EN Eyonganyoh… - International Journal of …, 2017 - scirp.org
A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from
benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by …

Design, synthesis, biological activity, molecular docking and computational studies on novel 1, 4-disubstituted-1, 2, 3-Triazole-Thiosemicarbazone hybrid molecules

RK Tittal, VD Ghule, N Kumar, L Kumar, K Lal… - Journal of Molecular …, 2020 - Elsevier
A library of some novel 1, 4-disubstituted-1, 2, 3-triazole-thiosemicarbazone hybrid
molecules were designed and synthesized from (4-Prop-2-ynyloxy-benzylidene) …

Synthesis, Theoretical, in Silico and in Vitro Biological Evaluation Studies of New Thiosemicarbazones as Enzyme Inhibitors

M Erdoğan, M Serdar Çavuş, H Muğlu… - Chemistry & …, 2023 - Wiley Online Library
Abstract Eleven new thiosemicarbazone derivatives (1–11) were designed from nine
different biologically and pharmacologically important isothiocyanate derivatives containing …

Thiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study

NP Prajapati, KD Patel, RH Vekariya, HD Patel… - Journal of Molecular …, 2019 - Elsevier
In the present study, series of novel compounds (E)-2-(1-(4-methyl-2-(substituted-
phenylamino) thiazol-5-yl) ethylidene) hydrazinecarbothio-amide (5a-j) and (E)-N …

In vitro and in vivo evaluation of the antimicrobial, antioxidant, cytotoxic, hemolytic activities and in silico POM/DFT/DNA-binding and pharmacokinetic analyses of …

SA Hassan, DM Aziz, MN Abdullah… - Journal of …, 2024 - Taylor & Francis
In this work, Schiff bases and Thiazolidin-4-ones, were synthesized using Sonication and
Microwave techniques, respectively. The Schiff base derivatives (3a–b) were synthesized …