Costimuli provide supplementary signals required by naive T cells to become fully activated
upon Ag encounter. Tetraspanins are a large family of transmembrane proteins that can …

Costimulatory signals via B7/CD28 family molecules (signal 2) are critical for effective
adaptive CD8+ T cell immune responses. In addition to costimulatory signals, B7/CD28 …

Chronic hepatitis C virus (HCV) infection frequently develops into liver disease and is
accompanied by extra‐hepatic autoimmune manifestations. The tetraspanin CD81 is a …

The lymphocytic CD81 molecule, capable of modulating type-1/-2 T-helper responses and
serving as a putative receptor for hepatitis C virus (HCV), might influence the outcome of anti …

Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure
and hepatocellular carcinoma. CD8+ T cell responses are important in the control of viremia …

Infection with hepatitis C virus (HCV) is a leading cause of chronic liver disease worldwide.
Little is known about how this virus is able to persist or whether this persistence might be …

Hepatitis C virus (HCV) infection is a major global health problem. Hepatic expression of
immune costimulatory signaling molecules (eg, B7) is known to be associated with ongoing …

CD81 (TAPA-1) is a ubiquitously expressed tetraspanin protein identified as a component of
the B lymphocyte receptor (BCR) and as a receptor for the Hepatitis C Virus. In an effort to …

CD4 T‐cell function is crucial for the eradication of HCV, and insufficient function is observed
in chronic carriers. The monitoring of T‐cell responses is complicated by the scarcity of …

Infection with hepatitis C virus (HCV) is still a major public health problem, and the events
leading to hepatocyte infection are not yet fully understood. Combining confocal microscopy …