Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate
promising results, many practical and mechanistic issues regarding this therapy remain …

Rationale: The regenerative potential of the heart is insufficient to fully restore functioning
myocardium after injury, motivating the quest for a cell-based replacement strategy. Bone …

Rodent and human clinical studies have shown that transplantation of bone marrow stem
cells to the ischemic myocardium results in improved cardiac function. In this study …

Myocardial infarction may cause sudden cardiac death and heart failure. Adult cardiac
myocytes do not replicate due to lack of a substantive pool of precursor, stem, or reserve …

Until recently, the concept of treating the injured or failing heart by generating new functional
myocardium was considered physiologically impossible. Major scientific strides in the past …

The ischemia-induced death of cardiomyocytes results in scar formation and reduced
contractility of the ventricle. Several preclinical and clinical studies have supported the …

Cardiovascular disease remains the leading cause of death worldwide. Acute ischaemic
injury and chronic cardiomyopathies lead to permanent loss of cardiac tissue and ultimately …

Clinical and basic studies of cell-based myocardial therapy have proceeded at a rapid pace.
Cell therapy could lead to successful cardiac regeneration or repair by any of three general …

OBJECTIVE: To review the milestones in stem cell therapy for ischemic heart disease from
early basic science to large clinical studies and new therapeutic approaches. MATERIALS …

Background—Systemic delivery of bone marrow–derived mesenchymal stem cells (BM-
MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat …