Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
LC Amado, AP Saliaris, KH Schuleri… - Proceedings of the …, 2005 - National Acad Sciences
Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate
promising results, many practical and mechanistic issues regarding this therapy remain …
promising results, many practical and mechanistic issues regarding this therapy remain …
Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
KE Hatzistergos, H Quevedo, BN Oskouei… - Circulation …, 2010 - Am Heart Assoc
Rationale: The regenerative potential of the heart is insufficient to fully restore functioning
myocardium after injury, motivating the quest for a cell-based replacement strategy. Bone …
myocardium after injury, motivating the quest for a cell-based replacement strategy. Bone …
Repair of Infarcted Myocardium Mediated by Transplanted Bone Marrow–Derived CD34+ Stem Cells in a Nonhuman Primate Model
T Yoshioka, N Ageyama, H Shibata, T Yasu… - Stem …, 2005 - academic.oup.com
Rodent and human clinical studies have shown that transplantation of bone marrow stem
cells to the ischemic myocardium results in improved cardiac function. In this study …
cells to the ischemic myocardium results in improved cardiac function. In this study …
Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart
M Kudo, Y Wang, MA Wani, M Xu, A Ayub… - Journal of molecular and …, 2003 - Elsevier
Myocardial infarction may cause sudden cardiac death and heart failure. Adult cardiac
myocytes do not replicate due to lack of a substantive pool of precursor, stem, or reserve …
myocytes do not replicate due to lack of a substantive pool of precursor, stem, or reserve …
Mesenchymal stem cells for cardiac regenerative therapy
Until recently, the concept of treating the injured or failing heart by generating new functional
myocardium was considered physiologically impossible. Major scientific strides in the past …
myocardium was considered physiologically impossible. Major scientific strides in the past …
Mesenchymal stem cells and the treatment of cardiac disease
JJ Minguell, A Erices - Experimental Biology and Medicine, 2006 - journals.sagepub.com
The ischemia-induced death of cardiomyocytes results in scar formation and reduced
contractility of the ventricle. Several preclinical and clinical studies have supported the …
contractility of the ventricle. Several preclinical and clinical studies have supported the …
Stem cell therapy for cardiac repair: benefits and barriers
SJ Joggerst, AK Hatzopoulos - Expert reviews in molecular medicine, 2009 - cambridge.org
Cardiovascular disease remains the leading cause of death worldwide. Acute ischaemic
injury and chronic cardiomyopathies lead to permanent loss of cardiac tissue and ultimately …
injury and chronic cardiomyopathies lead to permanent loss of cardiac tissue and ultimately …
Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche
R Mazhari, JM Hare - Nature Clinical Practice Cardiovascular Medicine, 2007 - nature.com
Clinical and basic studies of cell-based myocardial therapy have proceeded at a rapid pace.
Cell therapy could lead to successful cardiac regeneration or repair by any of three general …
Cell therapy could lead to successful cardiac regeneration or repair by any of three general …
[HTML][HTML] Role of adult bone marrow stem cells in the repair of ischemic myocardium: current state of the art
S Charwat, M Gyöngyösi, I Lang, S Graf, G Beran… - Experimental …, 2008 - Elsevier
OBJECTIVE: To review the milestones in stem cell therapy for ischemic heart disease from
early basic science to large clinical studies and new therapeutic approaches. MATERIALS …
early basic science to large clinical studies and new therapeutic approaches. MATERIALS …
Systemic delivery of bone marrow–derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution
IM Barbash, P Chouraqui, J Baron, MS Feinberg… - Circulation, 2003 - Am Heart Assoc
Background—Systemic delivery of bone marrow–derived mesenchymal stem cells (BM-
MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat …
MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat …
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