[HTML][HTML] Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD …

Y Zhao, V Jaber, WJ Lukiw - Frontiers in cellular and infection …, 2017 - frontiersin.org
Although the potential contribution of the human gastrointestinal (GI) tract microbiome to
human health, aging, and disease is becoming increasingly acknowledged, the molecular …

[HTML][HTML] Microbiome-derived lipopolysaccharide enriched in the perinuclear region of Alzheimer's disease brain

Y Zhao, L Cong, V Jaber, WJ Lukiw - Frontiers in Immunology, 2017 - frontiersin.org
Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological
data together indicate that there occur an unusual inflammatory reaction and a disruption of …

[HTML][HTML] Lipopolysaccharides (LPSs) as potent neurotoxic glycolipids in Alzheimer's disease (AD)

Y Zhao, VR Jaber, AI Pogue, NM Sharfman… - International Journal of …, 2022 - mdpi.com
Lipopolysaccharides (LPSs) are microbiome-derived glycolipids that are among the most
potent pro-inflammatory neurotoxins known. In Homo sapiens, the major sources of LPSs …

[HTML][HTML] Lipopolysaccharide (LPS) accumulates in neocortical neurons of Alzheimer's disease (AD) brain and impairs transcription in human neuronal-glial primary co …

Y Zhao, L Cong, WJ Lukiw - Frontiers in aging neuroscience, 2017 - frontiersin.org
Several independent laboratories have recently reported the detection of bacterial nucleic
acid sequences or bacterial-derived neurotoxins, such as highly inflammatory …

[HTML][HTML] Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer's Disease

WJ Lukiw - Frontiers in microbiology, 2016 - frontiersin.org
The human microbiome consists of~ 3.8× 1013 symbiotic microorganisms that form a highly
complex and dynamic ecosystem: the gastrointestinal (GI) tract constitutes the largest …

[HTML][HTML] Gastrointestinal (GI) tract microbiome-derived neurotoxins—potent neuro-inflammatory signals from the GI tract via the systemic circulation into the brain

WJ Lukiw - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
The microbiome of the human gastrointestinal (GI)-tract is a rich and dynamic source of
microorganisms that together possess a staggering complexity and diversity. Collectively …

[HTML][HTML] A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers

M Marizzoni, P Mirabelli, E Mombelli, L Coppola… - Alzheimer's Research & …, 2023 - Springer
Background Increasing evidence links the gut microbiota (GM) to Alzheimer's disease (AD)
but the mechanisms through which gut bacteria influence the brain are still unclear. This …

[HTML][HTML] The gastrointestinal tract microbiome and potential link to Alzheimer's disease

JM Hill, S Bhattacharjee, AI Pogue, WJ Lukiw - Frontiers in neurology, 2014 - frontiersin.org
Accumulating clinical-and scientific research-based evidence is driving our increased
awareness of the significance of the human microbiome (HM) to the healthy and …

[HTML][HTML] The gut microbiome alterations and inflammation-driven pathogenesis of Alzheimer's disease—a critical review

M Sochocka, K Donskow-Łysoniewska, BS Diniz… - Molecular …, 2019 - Springer
One of the most important scientific discoveries of recent years was the disclosure that the
intestinal microflora takes part in bidirectional communication between the gut and the brain …

[HTML][HTML] Role of endogenous lipopolysaccharides in neurological disorders

M Kalyan, AH Tousif, S Sonali, C Vichitra, T Sunanda… - Cells, 2022 - mdpi.com
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …