[HTML][HTML] Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD …
Y Zhao, V Jaber, WJ Lukiw - Frontiers in cellular and infection …, 2017 - frontiersin.org
Although the potential contribution of the human gastrointestinal (GI) tract microbiome to
human health, aging, and disease is becoming increasingly acknowledged, the molecular …
human health, aging, and disease is becoming increasingly acknowledged, the molecular …
[HTML][HTML] Microbiome-derived lipopolysaccharide enriched in the perinuclear region of Alzheimer's disease brain
Y Zhao, L Cong, V Jaber, WJ Lukiw - Frontiers in Immunology, 2017 - frontiersin.org
Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological
data together indicate that there occur an unusual inflammatory reaction and a disruption of …
data together indicate that there occur an unusual inflammatory reaction and a disruption of …
[HTML][HTML] Lipopolysaccharides (LPSs) as potent neurotoxic glycolipids in Alzheimer's disease (AD)
Y Zhao, VR Jaber, AI Pogue, NM Sharfman… - International Journal of …, 2022 - mdpi.com
Lipopolysaccharides (LPSs) are microbiome-derived glycolipids that are among the most
potent pro-inflammatory neurotoxins known. In Homo sapiens, the major sources of LPSs …
potent pro-inflammatory neurotoxins known. In Homo sapiens, the major sources of LPSs …
[HTML][HTML] Lipopolysaccharide (LPS) accumulates in neocortical neurons of Alzheimer's disease (AD) brain and impairs transcription in human neuronal-glial primary co …
Y Zhao, L Cong, WJ Lukiw - Frontiers in aging neuroscience, 2017 - frontiersin.org
Several independent laboratories have recently reported the detection of bacterial nucleic
acid sequences or bacterial-derived neurotoxins, such as highly inflammatory …
acid sequences or bacterial-derived neurotoxins, such as highly inflammatory …
[HTML][HTML] Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer's Disease
WJ Lukiw - Frontiers in microbiology, 2016 - frontiersin.org
The human microbiome consists of~ 3.8× 1013 symbiotic microorganisms that form a highly
complex and dynamic ecosystem: the gastrointestinal (GI) tract constitutes the largest …
complex and dynamic ecosystem: the gastrointestinal (GI) tract constitutes the largest …
[HTML][HTML] Gastrointestinal (GI) tract microbiome-derived neurotoxins—potent neuro-inflammatory signals from the GI tract via the systemic circulation into the brain
WJ Lukiw - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
The microbiome of the human gastrointestinal (GI)-tract is a rich and dynamic source of
microorganisms that together possess a staggering complexity and diversity. Collectively …
microorganisms that together possess a staggering complexity and diversity. Collectively …
[HTML][HTML] A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers
M Marizzoni, P Mirabelli, E Mombelli, L Coppola… - Alzheimer's Research & …, 2023 - Springer
Background Increasing evidence links the gut microbiota (GM) to Alzheimer's disease (AD)
but the mechanisms through which gut bacteria influence the brain are still unclear. This …
but the mechanisms through which gut bacteria influence the brain are still unclear. This …
[HTML][HTML] The gastrointestinal tract microbiome and potential link to Alzheimer's disease
JM Hill, S Bhattacharjee, AI Pogue, WJ Lukiw - Frontiers in neurology, 2014 - frontiersin.org
Accumulating clinical-and scientific research-based evidence is driving our increased
awareness of the significance of the human microbiome (HM) to the healthy and …
awareness of the significance of the human microbiome (HM) to the healthy and …
[HTML][HTML] The gut microbiome alterations and inflammation-driven pathogenesis of Alzheimer's disease—a critical review
One of the most important scientific discoveries of recent years was the disclosure that the
intestinal microflora takes part in bidirectional communication between the gut and the brain …
intestinal microflora takes part in bidirectional communication between the gut and the brain …
[HTML][HTML] Role of endogenous lipopolysaccharides in neurological disorders
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …
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