Highlights•The therapeutic principle of K v 1.5 inhibition for AF treatment is not understood.•I
Kur/K v 1.5 inhibition can result in action potential shortening in atrial cardiomyocytes.•Poor …

Atrial fibrillation (AF) is a common cardiac arrhythmia with potentially life-threatening
complications. Drug therapies for treatment of AF that seek long-term maintenance of normal …

Atrial fibrillation is the most common cardiac arrhythmia associated with heart failure, stroke
and mortality. Existing treatment of atrial fibrillation with class I or class III antiarrhythmic …

Atrial arrhythmias are a common problem in cardiological practice. Despite the availability of
several antiarrhythmic drugs there is a medical need for safer and more efficient treatments …

Atrial arrhythmias are a common problem in cardiological practice. Despite the availability of
several antiarrhythmic drugs, there is a medical need for safer and more efficient …

Selective blockers of the Kv1. 5 channel have been developed for the treatment of atrial
fibrillation (AF), but little is known how these atrial-selective drugs affect human action …

Aim: Despite promising effects of Kv1. 5 blockers in experimental models of atrial fibrillation,
limited data is available for man. Therefore we investigated two selective Kv1. 5 channel …

The treatment and prevention of atrial fibrillation (AF) remains a significant unmet medical
need. Existing therapies that maintain or restore sinus rhythm (rhythm control) have …

Introduction: Atrial fibrillation (AF) is the most common arrhythmia in humans. It is
progressive and the development of electrical and structural remodeling makes early …

The voltage-gated potassium channel Kv1. 5, which mediates the cardiac ultra-rapid
delayed-rectifier (I Kur) current in human cells, has a crucial role in atrial fibrillation …