The natural killer cell interferon-gamma response to bacteria is diminished in untreated HIV-1 infection and defects persist despite viral suppression

SM Dillon, EJ Lee, JM Bramante, E Barker… - JAIDS Journal of …, 2014 - journals.lww.com
Objective: Natural killer (NK) cells are important in innate immune responses to bacterial
and viral pathogens. HIV-1 infection is associated with opportunistic bacterial infections and …

Natural killer cell function is well preserved in asymptomatic human immunodeficiency virus type 2 (HIV-2) infection but similar to that of HIV-1 infection when CD4 T …

SV Nuvor, M van der Sande, S Rowland-Jones… - Journal of …, 2006 - Am Soc Microbiol
Natural killer (NK) cells are potent effectors of natural immunity and their activity prevents
human immunodeficiency virus type 1 (HIV-1) viral entry and viral replication. We sought to …

Natural killer cell responses in homosexual men with early HIV infection

Q Cai, XL Huang, G Rappocciolo… - JAIDS Journal of …, 1990 - journals.lww.com
Natural killer (NK) cells may be of significance in host defense against viral infections. In the
present study, NK cell function was examined in relation to different phases of human …

Natural killer cells in HIV-1 infection and therapy

J Mikulak, F Oriolo, E Zaghi, C Di Vito, D Mavilio - Aids, 2017 - journals.lww.com
Natural killer (NK) cells are important effectors of innate immunity playing a key role in the
eradication and clearance of viral infections. Over the recent years, several studies have …

Immune Reconstitution of CD56dim NK Cells in Individuals with Primary HIV-1 Infection Treated with Interleukin-2

J Michaëlsson, BR Long, CP Loo… - The Journal of …, 2008 - academic.oup.com
Natural killer (NK) cells are believed to play a role in human immunodeficiency virus type 1
(HIV-1) disease progression, and NK cell levels are reduced in individuals with chronic HIV …

Dysfunctional natural killer cells, in vivo, are governed by HIV viremia regardless of whether the infected individual is on antiretroviral therapy

E Barker, J Martinson, C Brooks, A Landay, S Deeks - Aids, 2007 - journals.lww.com
Progression to AIDS during HIV-infection is associated with a decrease in the number and
function of natural killer (NK) cells [1–4]. The reduction in NK cells expressing CD56 and …

Sustained impairment of IFN-γ secretion in suppressed HIV-infected patients despite mature NK cell recovery: evidence for a defective reconstitution of innate …

L Azzoni, E Papasavvas, J Chehimi… - The Journal of …, 2002 - journals.aai.org
The impairment of NK cell functions in the course of HIV infection contributes to a decreased
resistance against HIV and other pathogens. We analyzed the proportion of mature and …

Perturbation of natural killer cell function and receptors during HIV infection

KA Eger, D Unutmaz - Trends in microbiology, 2004 - cell.com
Natural killer (NK) cells play an important role in innate host defenses against a variety of
pathogens. A recent report described striking perturbations in the expression of NK cell …

Natural killer cell function in patients with acquired immunodeficiency syndrome and related diseases

BG Brenner, A Dascal, RG Margolese… - Journal of Leukocyte …, 1989 - Wiley Online Library
This review describes current knowledge of changes in natural killer (NK) cell function in
acquired immunodeficiency syndrome (AIDS)‐related disorders, vis‐à‐vis associated …

[HTML][HTML] Changes in Natural Killer cell activation and function during primary HIV-1 Infection

V Naranbhai, M Altfeld, SSA Karim, T Ndung'u… - PloS one, 2013 - journals.plos.org
Background Recent reports suggest that Natural Killer (NK) cells may modulate
pathogenesis of primary HIV-1 infection. However, HIV dysregulates NK-cell responses. We …