Despite accounting for only∼ 0.5% of the lung epithelium, pulmonary neuroendocrine cells
(PNECs) appear to play an outsized role in respiratory health and disease. Increased PNEC …

Mammalian lungs have the ability to recognize external environments by sensing different
compounds in inhaled air. Pulmonary neuroendocrine cells (PNECs) are rare, multi …

Pulmonary neuroendocrine cells (PNECs) are sensory cells within the lung airway epithelia.
Here, we provide a detailed protocol for generating induced PNECs (iPNECs) from human …

As a gas-exchange organ, the lung is constantly exposed to a diverse array of aerosol inputs
such as pollutants, allergens, pathogens and varying levels of oxygen. How the lung senses …

Expansion of pulmonary neuroendocrine cells (PNECs) is a pathological feature of many
human lung diseases. Human PNECs are inherently difficult to study due to their rarity (< 1 …

While the lung is commonly known for its gas exchange function, it is exposed to signals in
the inhaled air and responds to them by collaborating with other systems including immune …

Pulmonary neuroendocrine cells (PNECs) have been around for 60 years in the scientific
literature, although phylogenetically they are ancient. Their traditionally ascribed functions …

Pulmonary neuroendocrine cells (PNECs) are proposed to be the first specialized cell type
to appear in the lung, but their ontogeny remains obscure. Although studies of PNECs have …

Pulmonary neuroendocrine cells (PNECs) have crucial roles in airway physiology and
immunity by producing bioactive amines and neuropeptides (NPs). A variety of human …

Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely
harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond …