The multidimensional therapeutic potential of targeting the brain oxytocin system for the treatment of substance use disorders

MT Bowen, ID Neumann - Behavioral Pharmacology of Neuropeptides …, 2018 - Springer
The neuropeptide oxytocin is released both into the blood and within the brain in response
to reproductive stimuli, such as birth, suckling and sex, but also in response to social …

Targeting the oxytocin system to treat addictive disorders: rationale and progress to date

MR Lee, MCH Rohn, G Tanda, L Leggio - CNS drugs, 2016 - Springer
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …

Unraveling oxytocin's peripheral vs. central mechanisms

CM Reichel - Neuropsychopharmacology, 2021 - nature.com
To date, very few pharmacological treatments for addiction have crossed the bridge of
translational relevance. The arduous journey often begins with early victories in preclinical …

Barriers and breakthroughs in targeting the oxytocin system to treat alcohol use disorder

AE Ryabinin, Y Zhang - Frontiers in Psychiatry, 2022 - frontiersin.org
Development of better treatments for alcohol use disorder (AUD) is urgently needed. One
promising opportunity for this development is the potential of targeting the oxytocin peptide …

Rebalancing the addicted brain: oxytocin interference with the neural substrates of addiction

MT Bowen, ID Neumann - Trends in neurosciences, 2017 - cell.com
Drugs that act on the brain oxytocin (OXT) system may provide a much-needed treatment
breakthrough for substance-use disorders. Targeting the brain OXT system has the potential …

Oxytocin for the treatment of drug and alcohol use disorders

MR Lee, EM Weerts - Behavioural pharmacology, 2016 - journals.lww.com
There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and
other substance-use disorders. OT is a neuropeptide that modulates adaptive processes …

Oxytocin and rodent models of addiction

KC Leong, S Cox, C King, H Becker… - International review of …, 2018 - Elsevier
Interest for the use of oxytocin as a treatment for addiction began over 40 years ago. Better
known for its roles in parturition, lactation and pair bonding, oxytocin also has anxiolytic …

Brain oxytocin: how puzzle stones from animal studies translate into psychiatry

V Grinevich, ID Neumann - Molecular psychiatry, 2021 - nature.com
The neuropeptide oxytocin has attracted great attention of the general public, basic
neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social …

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges

X Che, J Cai, Y Liu, T Xu, J Yang, C Wu - Pharmacology & therapeutics, 2021 - Elsevier
Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

The potential role of oxytocin in addiction: What is the target process?

F Sanna, MA De Luca - Current Opinion in Pharmacology, 2021 - Elsevier
Oxytocin regulates a variety of centrally-mediated functions, ranging from socio-sexual
behavior, maternal care, and affiliation to fear, stress, anxiety. In the past years, both clinical …