Background—Inappropriately sustained inflammation is a hallmark of chronic ischemic heart
failure (HF); however, the pathophysiological role of T lymphocytes is unclear. Methods and …

Background—Despite the emerging association between heart failure (HF) and
inflammation, the role of T cells, major players in chronic inflammation, has only recently …

Myocardial inflammation can lead to lethal acute or chronic heart failure (HF). T lymphocytes
(T cells), have been reported in the inflamed heart in different etiologies of HF, and more …

Background: Heart failure (HF) is a state of inappropriately sustained inflammation,
suggesting the loss of normal immunosuppressive mechanisms. Regulatory T-lymphocytes …

CD4+ T-cells facilitate wound healing post-myocardial infarction (MI) but promote left-
ventricular (LV) remodeling during ischemic heart failure (HF; 8 weeks post-MI). Therefore, it …

Rationale: The role of mononuclear phagocytes in chronic heart failure (HF) is unknown.
Objective: Our aim was to delineate monocyte, macrophage, and dendritic cell trafficking in …

CD4+ T cells turn pathological during heart failure (HF). We show that the expression of
tumor necrosis factor (TNF)-α and tumor necrosis factor receptor (TNFR1) increases in HF …

Objective: Lymphatics play an essential pathophysiological role in promoting fluid and
immune cell tissue clearance. Conversely, immune cells may influence lymphatic function …

Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders
massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to …

Inflammation is a well‐known feature of heart failure. Studies have shown that while some
inflammation is required for repair during injury and is protective, prolonged inflammation …