Diabetic cardiomyopathy has been systematically associated with compromised
mitochondrial energetics and increased generation of reactive oxygen species (ROS) that …

Diabetic cardiomyopathy is preceded by mitochondrial alterations, and progresses to heart
failure. We studied whether treatment with methylene blue (MB), a compound that was …

The heart is one of the organs affected during the later stages of diabetes. Mitochondrial
function has already been proposed to be affected during the course of diabetes …

Diabetes is a chronic disease associated to a cardiac contractile dysfunction that is not
attributable to underlying coronary artery disease or hypertension, and could be …

Altered cellular mitochondrial membrane potential (MMP) has been implicated in the
increased insulin resistance and the risk for diabetes. Hyperketonemia is increasingly being …

The objective of the present study was to delineate the molecular mechanisms for
mitochondrial contribution to oxidative stress induced by hypoxia and reoxygenation in the …

Intracellular Na+ is approximately two times higher in diabetic cardiomyocytes than in
control. We hypothesized that the increase in Na+ 1 activates the mitochondrial membrane …

According to the literature, methylene blue (MB) is a photosensitizer (PS) with a high affinity
for mitochondria. Therefore, several studies have explored this feature to evaluate its …

Purpose Oxidative stress causes mitochondrial dysfunction in myocardial
ischaemia/reperfusion (I/R) as well as in obesity. Mitochondrial depolarization triggers …

The redox dye methylene blue (MB) is proven to have beneficial effects in various models of
neurodegenerative diseases. Here we investigated the effects of MB (100 nM, 300 nM, and …