Grapefruit juice produces mechanism‐based inhibition of intestinal drug metabolism when
consumed in normal quantities. This can produce clinically important increases in oral drug …

Grapefruit juice (GFJ) interacts with a number of drugs, and can alter pharmacokinetics
parameters of the drugs. As for these interactions, most reports have focused on the …

More than a decade has passed since it was unintentionally discovered that grapefruit juice
interacts with certain drugs. The coadministration of these drugs with grapefruit juice can …

Background: Grapefruit juice is known to alter the pharmacokinetics of over 30 prescription
drugs by increasing their bioavailabilities. After the discovery of this interaction almost 20 …

There is widespread recognition that the ingestion of a meal is associated with a number of
physiologic changes (gastric pH, gastric emptying, hepatic blood flow, etc.) that can …

The goals of this study were to assess the extent of human intestinal drug transporter
expression, determine the subcellular localization of the drug uptake transporter OATP1A2 …

Concomitant administration of grapefruit juice can increase the plasma concentration of
numerous drugs in humans and decrease the concentration of a few others. Such elevations …

Introduction: Since their initial discovery in 1989, grapefruit juice (GFJ)–drug interactions
have received extensive interest from the scientific, medical, regulatory and lay communities …

Most drugs are taken orally. For those intended to act systemically, a significant fraction of
the dose can be eliminated during its first passage through a sequence of organs before …

A new type of interaction in which fruit juices diminish oral drug bioavailability through
inhibition of uptake transport is the focus of this review. The discovery was based on an …