Ca2+-dependent signaling is highly regulated in cardiomyocytes and determines the force
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

Congestive heart failure is the leading cause of death in the Western world. Abnormal
intracellular calcium (Ca2+) handling is central to the pathogenesis of heart failure because …

The cardiac ryanodine receptor (RyR2) located on the sarcoplasmic reticulum (SR) controls
intracellular Ca2+ release and muscle contraction in the heart. Ca2+ release via RyR2 is …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

The cardiac ryanodine receptor (RyR2)/Ca2 release channel on the sarcoplasmic reticulum
(SR) is regulated by evolutionarily highly conserved signaling pathways that control …

Defective regulation of the cardiac ryanodine receptor (RyR2)/calcium release channel,
required for excitation-contraction coupling in the heart, has been linked to cardiac …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

The cardiac sarcoplasmic reticulum calcium release channel, commonly referred to as the
ryanodine receptor, is a key component in cardiac excitation–contraction coupling, where it …

Abstract Regulation of Calcium (Ca) cycling by the sarcoplasmic reticulum (SR) underlies
the control of cardiac contraction during excitation-contraction (EC) coupling. Moreover …