Calcium cycling proteins and heart failure: mechanisms and therapeutics
AR Marks - The Journal of clinical investigation, 2013 - Am Soc Clin Investig
Ca2+-dependent signaling is highly regulated in cardiomyocytes and determines the force
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …
Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy
C Kho, A Lee, RJ Hajjar - Nature Reviews Cardiology, 2012 - nature.com
Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …
Novel therapeutic approaches for heart failure by normalizing calcium cycling
XHT Wehrens, AR Marks - Nature Reviews Drug Discovery, 2004 - nature.com
Congestive heart failure is the leading cause of death in the Western world. Abnormal
intracellular calcium (Ca2+) handling is central to the pathogenesis of heart failure because …
intracellular calcium (Ca2+) handling is central to the pathogenesis of heart failure because …
Cardiac ryanodine receptor function and regulation in heart disease
SE Lehnart, XHT Wehrens, A Kushnir… - Annals of the New …, 2004 - Wiley Online Library
The cardiac ryanodine receptor (RyR2) located on the sarcoplasmic reticulum (SR) controls
intracellular Ca2+ release and muscle contraction in the heart. Ca2+ release via RyR2 is …
intracellular Ca2+ release and muscle contraction in the heart. Ca2+ release via RyR2 is …
RyR2 and calcium release in heart failure
JP Benitah, R Perrier, JJ Mercadier, L Pereira… - Frontiers in …, 2021 - frontiersin.org
Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor?
The cardiac ryanodine receptor (RyR2)/Ca2 release channel on the sarcoplasmic reticulum
(SR) is regulated by evolutionarily highly conserved signaling pathways that control …
(SR) is regulated by evolutionarily highly conserved signaling pathways that control …
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression
XHT Wehrens, SE Lehnart, S Reiken… - Proceedings of the …, 2006 - National Acad Sciences
Defective regulation of the cardiac ryanodine receptor (RyR2)/calcium release channel,
required for excitation-contraction coupling in the heart, has been linked to cardiac …
required for excitation-contraction coupling in the heart, has been linked to cardiac …
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
The cardiac ryanodine receptor (calcium release channel) Emerging role in heart failure and arrhythmia pathogenesis
M Scoote, AJ Williams - Cardiovascular research, 2002 - academic.oup.com
The cardiac sarcoplasmic reticulum calcium release channel, commonly referred to as the
ryanodine receptor, is a key component in cardiac excitation–contraction coupling, where it …
ryanodine receptor, is a key component in cardiac excitation–contraction coupling, where it …
Calcium and cardiomyopathies
EG Kranias, DM Bers - … Signalling and Disease: Molecular Pathology of …, 2007 - Springer
Abstract Regulation of Calcium (Ca) cycling by the sarcoplasmic reticulum (SR) underlies
the control of cardiac contraction during excitation-contraction (EC) coupling. Moreover …
the control of cardiac contraction during excitation-contraction (EC) coupling. Moreover …
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