With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …

Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …

Background and methods: Host genomic alterations are closely related to dysfunction of
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …

Background The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the
promoter and intragenic regions. DNA methylation in the promoter region has been shown …

GWAS, immune analyses and biomarker screenings have identified host factors associated
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …

Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …

ABSTRACT DNA methylation is an epigenetic mechanism most commonly associated with
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …

Background Previous epigenome-wide association studies have shown that HIV infection
can disrupt the host DNA methylation landscape. However, it remains unclear how …

DNA methylation is one of the epigenetic modifications that configures gene transcription
programs. This study describes the DNA methylation profile of HIV-infected individuals with …

Alteration of DNA methylation in mammalian cells could be elicited by many factors,
including viral infections [1]. HIV has shown the ability to interact with host cellular factors to …