Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …
The environmental factors affect the human body by modifying its epigenetics, which …
Genome-wide characterization of host transcriptional and epigenetic alterations during HIV infection of T lymphocytes
X Zeng, JCC Tsui, M Shi, J Peng, CY Cao… - Frontiers in …, 2020 - frontiersin.org
Background and methods: Host genomic alterations are closely related to dysfunction of
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals
Background The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
B Oriol-Tordera, M Berdasco, A Llano, B Mothe… - PLoS …, 2020 - journals.plos.org
GWAS, immune analyses and biomarker screenings have identified host factors associated
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …
Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
Challenges in quantifying cytosine methylation in the HIV provirus
ABSTRACT DNA methylation is an epigenetic mechanism most commonly associated with
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns
A Esteban-Cantos, J Rodríguez-Centeno, JC Silla… - …, 2023 - thelancet.com
Background Previous epigenome-wide association studies have shown that HIV infection
can disrupt the host DNA methylation landscape. However, it remains unclear how …
can disrupt the host DNA methylation landscape. However, it remains unclear how …
Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response
DNA methylation is one of the epigenetic modifications that configures gene transcription
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
[HTML][HTML] Genome-wide analysis of DNA methylation associated with HIV infection based on a pair of monozygotic twins
Y Zhang, SK Li, SKW Tsui - Genomics Data, 2015 - Elsevier
Alteration of DNA methylation in mammalian cells could be elicited by many factors,
including viral infections [1]. HIV has shown the ability to interact with host cellular factors to …
including viral infections [1]. HIV has shown the ability to interact with host cellular factors to …
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