Network Pharmacology and Experimental Validation to Explore the Potential Mechanism of Nigella sativa for the Treatment of Breast Cancer

R Arif, SA Bukhari, G Mustafa, S Ahmed, MF Albeshr - Pharmaceuticals, 2024 - mdpi.com
Breast cancer is a prevalent and potentially life-threatening disease that affects women
worldwide. Natural products have gained attention as potential anticancer agents due to …

Network pharmacology and multitarget analysis of Nigella sativa in the management of diabetes and obesity: a computational study

M Saleem, M Mazhar Fareed… - Journal of …, 2024 - Taylor & Francis
Obesity and diabetes are commonly associated with one another and represent a significant
global health issue, with a recent surge in disease incidence. Nigella sativa, also known as …

In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer

I Zafar, A Safder, H Imran Afridi, S Riaz… - Frontiers in …, 2023 - frontiersin.org
Introduction: Breast cancer poses a significant global challenge, prompting researchers to
explore novel approaches for potential treatments. Material and Methods: For in vitro study …

Assessing the anti-cancer therapeutic mechanism of a herbal combination for breast cancer on system-level by a network pharmacological approach

HS Lee, DS Oh - Anticancer Research, 2020 - ar.iiarjournals.org
Background/Aim: Accumulating evidence has shown therapeutic effects of herbals on breast
cancer, a commonly diagnosed malignancy in women worldwide. However, their underlying …

Mechanism of Solanum nigrum in treatment of breast cancer based on network pharmacology, molecular docking and in vitro experimental verifcation

WEN Xin, HU Jin-hang, C Min… - NATURAL PRODUCT …, 2023 - trcw.ac.cn
To explore the mechanism of action of Solanum nigrum in the treatment of breast cancer
based on network pharmacology and cellular experiments. The TCMSP database, Swiss …

Probing the mechanism of action (MOA) of Solanum nigrum Linn against breast cancer using network pharmacology and molecular docking

Y Song, MK Sakharkar, J Yang - SN Applied Sciences, 2023 - Springer
Solanum nigrum Linn is a medicinal herb widely used in traditional Chinese medicine to
treat ailments such as fever, inflammation and cancer. Although quite a few compounds …

Network pharmacology-based screening of active constituents of Avicennia marina and their clinical biochemistry related mechanism against breast cancer

FF Alshehri, ZS Alshehri - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Breast cancer is the second major cause of cancer death in women globally. Avicennia
marina is a medicinal plant that belongs to the family Acanthaceae and is known as grey or …

A Network Pharmacology Analysis of the Systems-Perspective Anticancer Mechanisms of the Herbal Drug FDY2004 for Breast Cancer

HS Lee, IH Lee, K Kang, SI Park… - Natural Product …, 2021 - journals.sagepub.com
Breast cancer is a malignant tumor with high incidence, prevalence, and mortality rates in
women. In recent years, herbal drugs have been assessed as anticancer therapy against …

In silico targeting breast cancer biomarkers by applying rambutan (Nephelium lappaceum) phytocompounds

S Parvizpour, A Elengoe, E Alizadeh… - Journal of …, 2023 - Taylor & Francis
Worldwide, breast cancer is the leading type of cancer among women. Overexpression of
various prognostic indicators, including nuclear receptors, is linked to breast cancer …

Uncovering the molecular mechanism of Gynostemma pentaphyllum (Thunb.) Makino against breast cancer using network pharmacology and molecular docking

WX Wang, XY He, DY Yi, XY Tan, LJ Wu, N Li… - Medicine, 2022 - journals.lww.com
Because of their strong anti-cancer efficacy with fewer side effects, traditional Chinese
medicines (TCM) have attracted considerable attention for their potential application in …