Mass spectrometry (MS)-based phosphoproteomics has achieved extraordinary success in
qualitative and quantitative analysis of cellular protein phosphorylation. Considering that an …

Phosphoproteomics can provide insights into cellular signaling dynamics. To achieve deep
and robust quantitative phosphoproteomics profiling for minute amounts of sample, we here …

Phosphorylation of proteins is one of the most prominent PTMs and for instance a key
regulator of signal transduction. In order to improve our understanding of cellular …

Reversible protein phosphorylation serves as a basis for regulating a number of cellular
processes. Aberrant activation of kinase signaling pathways is commonly associated with …

Mass spectrometry has transformed the field of cell signaling by enabling global studies of
dynamic protein phosphorylation ('phosphoproteomics'). Recent developments are enabling …

Despite decades of cancer research, mortality rates remain high largely due to the failure of
early detection, poor understanding of the epidemiology of rational drug targets, and …

Comprehensive mass spectrometry (MS)-based proteomics is now feasible, but
reproducible quantification remains challenging, especially for post-translational …

Protein phosphorylation serves as a primary mechanism of signal transduction in the cells of
biological organisms. Technical advancements over the last several years in mass …

Protein phosphorylation is a key regulator of cellular signaling pathways. It is involved in
most cellular events in which the complex interplay between protein kinases and protein …

Phosphorylation is one of the quickest post-translational modifications that controls
downstream signaling pathways regulating processes like cell proliferation, survival, and …