The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

Temporal and spatial specificity of gene expression is highly regulated through a rich milieu
of regulatory DNAs embedded in the genome. Enhancers represent a major class of …

The three-dimensional regulation of gene transcription involves loop formation between
enhancer and promoter elements, controlling spatiotemporal gene expression in …

Regulatory elements (enhancers) that are remote from promoters play a critical role in the
spatial, temporal, and physiological control of gene expression. Studies on specific loci …

Developmental enhancers mediate on/off patterns of gene expression in specific cell types
at particular stages during metazoan embryogenesis. They typically integrate multiple …

Gene expression requires successful communication between enhancer and promoter
regions, whose activities are regulated by a variety of factors and associated with distinct …

The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Enhancers establish spatial or temporal patterns of gene expression that are critical for
development, yet our understanding of how these DNA cis-regulatory elements function from …

Enhancers are distally located genomic cis-regulatory elements that integrate
spatiotemporal cues to coordinate gene expression in a tissue-specific manner during …