The role of epithelial damage in the pulmonary immune response
Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …
and are responsible for coordinating the innate immune response to injury and subsequent …
Ageing mechanisms that contribute to tissue remodeling in lung disease
M Schuliga, J Read, DA Knight - Ageing research reviews, 2021 - Elsevier
Age is a major risk factor for chronic respiratory diseases such as idiopathic pulmonary
fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and certain phenotypes of …
fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and certain phenotypes of …
Epithelial cells and inflammation in pulmonary wound repair
A Croasdell Lucchini, NN Gachanja, AG Rossi… - Cells, 2021 - mdpi.com
Respiratory diseases are frequently characterised by epithelial injury, airway inflammation,
defective tissue repair, and airway remodelling. This may occur in a subacute or chronic …
defective tissue repair, and airway remodelling. This may occur in a subacute or chronic …
The aging lung: Physiology, disease, and immunity
JL Schneider, JH Rowe, C Garcia-de-Alba, CF Kim… - Cell, 2021 - cell.com
The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
Cellular senescence: pathogenic mechanisms in lung fibrosis
Pulmonary fibrosis is a chronic and fatal lung disease that significantly impacts the aging
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …
[PDF][PDF] Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside
In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …
The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis
Pulmonary fibrosis is a chronic debilitating condition characterized by progressive
deposition of connective tissue, leading to a steady restriction of lung elasticity, a decline in …
deposition of connective tissue, leading to a steady restriction of lung elasticity, a decline in …
Danger-associated molecular patterns and danger signals in idiopathic pulmonary fibrosis
CD Ellson, R Dunmore, CM Hogaboam… - American journal of …, 2014 - atsjournals.org
The chronic debilitating lung disease, idiopathic pulmonary fibrosis (IPF), is characterized by
a progressive decline in lung function, with a median mortality rate of 2–3 years after …
a progressive decline in lung function, with a median mortality rate of 2–3 years after …
The epithelial-immune crosstalk in pulmonary fibrosis
T Planté-Bordeneuve, C Pilette, A Froidure - Frontiers in immunology, 2021 - frontiersin.org
Interactions between the lung epithelium and the immune system involve a tight regulation
to prevent inappropriate reactions and have been connected to several pulmonary diseases …
to prevent inappropriate reactions and have been connected to several pulmonary diseases …
After the storm: regeneration, repair, and reestablishment of homeostasis between the alveolar epithelium and innate immune system following viral lung injury
JD Planer, EE Morrisey - Annual Review of Pathology …, 2023 - annualreviews.org
The mammalian lung has an enormous environmental-epithelial interface that is optimized
to accomplish the principal function of the respiratory system, gas exchange. One …
to accomplish the principal function of the respiratory system, gas exchange. One …