By-products of disinfection were tested for initiating and/or promoting activity in rat liver by
using the rat liver foci bioassay. The assay uses an increased incidence of gamma …

Chloroform and other trihalomethanes are contaminants of drinking water that have been
demonstrated to be carcinogenic in laboratory animals. Determination of the mechanism of …

An initiation/promotion bioassay for chemical carcinogens and tumor promoters has been
developed in rat liver using presumed preneoplastic lesions, foci of gamma …

Concern related to possible cancer risks associated with disinfection by-products arose with
the publications of Rook (1974) and Bellar et al.(1974) that four trihalomethanes are …

The effect of subsequent administration of chloroform or phenobarbital on the incidence of
ethylnitrosourea (ENU) initiated liver and lung tumors was investigated. Fifteen day old …

The initiating and promoting activities of 1, 2-dibromoethane in rat liver were investigated
using the enzyme-altered foci bioassay. The incidence of γ-glutamyl-transpeptidase (GGT) …

In this study we demonstrate that chloroform, a widely used industrial solvent, a medicinal
chemical and a common drinking water contaminant, reduces the number of detectable …

Chloroform (CHCl3) and bromodichloromethane (CHBrCl2) are the two most common
haloorganic contaminants of chlorinated drinking water. A significantly increased incidence …

Estimation of health hazards associated with the widespread distribution of small amounts of
chemical carcinogens in drinking water presents a complex problem. However, it is …

Nine chlorinated aliphatics (CAs) were examined in a rat liver foci assay for tumor initiating
and promoting activities. In this model, young adult male Osborne Mendel rats were first …