Biomechanics of the JCT and SC Inner Wall Endothelial Cells with Their Basement Membrane Using 3D Serial Block-Face Scanning Electron Microscopy

A Karimi, R Razaghi, MJ Kelley, TS Acott, H Gong - Bioengineering, 2023 - mdpi.com
Background: More than~ 70% of the aqueous humor exits the eye through the conventional
aqueous outflow pathway that is comprised of the trabecular meshwork (TM) …

Modeling the biomechanics of the conventional aqueous outflow pathway microstructure in the human eye

A Karimi, R Razaghi, SM Rahmati, JC Downs… - Computer methods and …, 2022 - Elsevier
Background and objective Intraocular pressure (IOP) is determined by aqueous humor
outflow resistance, which is a function of the combined resistance of Schlemm's canal (SC) …

Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork

J Zhang, L Ren, X Mei, Q Xu, W Zheng, Z Liu - BioMedical Engineering …, 2016 - Springer
Background The intraocular pressure (IOP) is maintained through a dynamic equilibrium
between the production and drainage of aqueous humor. Elevation of intraocular pressure is …

Implementing new computational methods for the study of JCT and SC inner wall basement membrane biomechanics and hydrodynamics

A Karimi, R Razaghi, SD D'costa, S Torbati… - Computer Methods and …, 2024 - Elsevier
Purpose The conventional aqueous outflow pathway, which includes the trabecular
meshwork (TM), juxtacanalicular tissue (JCT), and the inner wall endothelium of Schlemm's …

The effect of intraocular pressure load boundary on the biomechanics of the human conventional aqueous outflow pathway

A Karimi, R Razaghi, SM Rahmati, JC Downs, TS Acott… - Bioengineering, 2022 - mdpi.com
Background: Aqueous humor outflow resistance in the trabecular meshwork (TM),
juxtacanalicular connective tissue (JCT), and Schlemm's canal (SC) endothelium of the …

Morphological and biomechanical analyses of the human healthy and glaucomatous aqueous outflow pathway: Imaging-to-modeling

A Karimi, DJ Crouch, R Razaghi, JC Downs… - Computer methods and …, 2023 - Elsevier
Abstract Background and Objective: Intraocular pressure (IOP) is maintained via a dynamic
balance between the production of aqueous humor and its drainage through the trabecular …

Viscoelastic biomechanical properties of the conventional aqueous outflow pathway tissues in healthy and glaucoma human eyes

A Karimi, R Razaghi, S Padilla, SM Rahmati… - Journal of clinical …, 2022 - mdpi.com
Background: Although the tissues comprising the ocular conventional outflow pathway have
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …

Developing an experimental-computational workflow to study the biomechanics of the human conventional aqueous outflow pathway

A Karimi, S Khan, R Razaghi, SM Rahmati, M Gathara… - Acta Biomaterialia, 2023 - Elsevier
The aqueous humor actively interacts with the trabecular meshwork (TM), juxtacanalicular
tissue (JCT), and Schlemm's canal (SC) through a dynamic fluid-structure interaction (FSI) …

Segmental biomechanics of the normal and glaucomatous human aqueous outflow pathway

A Karimi, S Khan, R Razaghi, M Aga, SM Rahmati… - Acta Biomaterialia, 2024 - Elsevier
The conventional aqueous outflow pathway, encompassing the trabecular meshwork (TM),
juxtacanalicular connective tissue (JCT), and inner wall endothelium of Schlemm's canal …

A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy

H Gong, J Ruberti, D Overby, M Johnson… - Experimental eye …, 2002 - Elsevier
Conventional transmission electron microscopic (TEM) images of the juxtacanalicular tissue
(JCT) region of the trabecular meshwork (TM) show flow passages that are much too large to …