The history of digitalis is rich and interesting, with the first use usually attributed to William
Withering and his study on the foxglove published in 1785. However, some knowledge of …

Digitalis is the oldest compound in cardiovascular medicine that continues to be used in
contemporary clinical practice. 1 Evidence supporting the beneficial effects of digoxin on …

Evidence-based medicine is an evolutionary process, intended to foster and disseminate the
best practice guidelines from an ongoing critical analysis of available data. An …

After 200 years of use, digitalis still appears to have a place in our armamentarium for heart
failure and atrial fibrillation despite the proven survival benefits with ACE inhibitors and β …

After 230 years of use, digitalis remains an important and useful therapy for patients with
atrial fibrillation, heart failure, and the 30–50% of patients with both conditions. Although the …

The intestinal absorption of digoxin is essentially a passive non-saturable diffusion process,
although a saturable carrier-mediated component also plays an important role. The …

Although digitalis glycosides were introduced in the treatment of cardiac maladies> 200
years ago, controversy persists regarding the precise role of digoxin in any multidrug …

Digoxin remains an important therapeutic option for the outpatient management of patients
with chronic symptomatic heart failure caused by systolic dysfunction. Randomized control …

Heart failure (HF) and atrial fibrillation (AF) are both highly prevalent diseases and a
significant proportion of patients with HF have concomitant AF [1]. Whereas HF is a risk …

Objectives: We sought to determine whether there was a relationship between serum
digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy …