Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis

YG Han, J Wu, ZY Gong, YQ Zhou, HB Li… - Journal of Translational …, 2021 - Springer
Background Osteoarthritis (OA), which is due to the progressive loss and degeneration of
articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great …

Screening of osteoarthritis diagnostic markers based on immune-related genes and immune infiltration

WH Yuan, QQ Xie, KP Wang, W Shen, XF Feng… - Scientific Reports, 2021 - nature.com
Osteoarthritis (OA) is a chronic degenerative disease of the bone and joints. Immune-related
genes and immune cell infiltration are important in OA development. We analyzed immune …

Identification of key biomarkers and immune infiltration in the synovial tissue of osteoarthritis by bioinformatics analysis

W Cai, H Li, Y Zhang, G Han - PeerJ, 2020 - peerj.com
Background Osteoarthritis (OA) is the most common chronic degenerative joint disease and
is mainly characterized by cartilage degeneration, subcartilage bone hyperplasia …

Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling …

R Zhang, X Yang, J Wang, L Han… - Molecular …, 2019 - spandidos-publications.com
The present study aimed to identify potential novel biomarkers in synovial tissue obtained
from patients with Rheumatoid Arthritis (RA) and Osteoarthritis (OA) for differential diagnosis …

Analysis of differentially expressed genes between rheumatoid arthritis and osteoarthritis based on the gene co‑expression network

QY Lu, QH Han, X Li, ZC Li… - Molecular …, 2014 - spandidos-publications.com
The aim of the current study was to investigate disease‑associated genes and related
molecular mechanisms of osteoarthritis (OA) and rheumatoid arthritis (RA). Using GSE7669 …

[HTML][HTML] Bioinformatics-led discovery of osteoarthritis biomarkers and inflammatory infiltrates

X Hu, S Ni, K Zhao, J Qian, Y Duan - Frontiers in Immunology, 2022 - frontiersin.org
The molecular mechanisms of osteoarthritis, the most common chronic disease, remain
unexplained. This study aimed to use bioinformatic methods to identify the key biomarkers …

Identification of four-gene signature to diagnose osteoarthritis through bioinformatics and machine learning methods

Z Chen, W Wang, Y Zhang, Y Hua - Cytokine, 2023 - Elsevier
Background Although osteoarthritis (OA) is one of the most prevalent joint disorders,
effective biomarkers to diagnose OA are still unavailable. This study aimed to acquire some …

Identification of differentially expressed genes, signaling pathways and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis

Y Ge, L Zhou, Z Chen, Y Mao, T Li, P Tong, L Shan - Hereditas, 2021 - Springer
Background The disability rate associated with rheumatoid arthritis (RA) ranks high among
inflammatory joint diseases. However, the cause and potential molecular events are as yet …

[HTML][HTML] Weighted gene co-expression network analysis reveals specific modules and hub genes related to immune infiltration of osteoarthritis

J Cao, H Ding, J Shang, L Ma, Q Wang… - Annals of translational …, 2021 - ncbi.nlm.nih.gov
Background The incidence of osteoarthritis (OA), a chronic degenerative disease, is
increasing every year. There is no effective clinical treatment for OA and the pathological …

Three hematologic/immune system-specific expressed genes are considered as the potential biomarkers for the diagnosis of early rheumatoid arthritis through …

Q Cheng, X Chen, H Wu, Y Du - Journal of translational medicine, 2021 - Springer
Background Rheumatoid arthritis (RA) is the most common chronic autoimmune connective
tissue disease. However, early RA is difficult to diagnose due to the lack of effective …