Abstract Development of effective cancer therapeutic strategies relies on our ability to
interfere with cellular processes that are dysregulated in tumors. Given the essential role of …

The ubiquitin proteasome system (UPS) is essential in regulating myriad aspects of protein
functions. It is therefore a fundamentally important regulatory mechanism that impacts most if …

The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular
physiology that tightly regulates cellular protein concentrations with specificity and precision …

The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …

Simple Summary The ubiquitin-proteasome system regulates multiple facets of protein
homeostasis to modulate signal transduction in numerous biological processes. Not …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

Simple Summary The ubiquitin proteasome system (UPS) governs the non-lysosomal
degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. Dysregulation …

Regulated protein turnover via the ubiquitin–proteasome system (UPS) underlies a wide
variety of signalling pathways, from cell-cycle control and transcription to development …

The ubiquitin proteasomal system (UPS) represents a highly regulated protein degradation
pathway essential for maintaining cellular homeostasis. This system plays a critical role in …

Ubiquitination is a reversible post-translational modification based on the chemical addition
of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination …