Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

The concept that adenine and uridine nucleotides function as extracellular signaling
molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of
intercellular communication, signaling via nucleotides. The signaling cascades involved in …

The modulatory role of extracellular nucleotides and adenosine in relevance to purinergic
cell signaling mechanisms has long been known and is an object of much research …

Ectonucleotidases are key for purinergic signaling. They control the duration of activity of
purinergic receptor agonists. At the same time, they produce hydrolysis products as …

Within the past 10 years the field of signaling via extracellular nucleotides has witnessed a
breath-taking expansion. Molecular cloning of receptors and physiological and …

Interest for extracellular nucleotides has increased since the pioneer work of Burnstock in
the early seventies. Research on cellular functions modulated by purines and pyrimidines …

Nucleotides are important extracellular signaling molecules. At least five mammalian P2Y
receptors exist that are specifically activated by ATP, UTP, ADP, or UDP. Although the …