Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage
degeneration. OA Patients are commonly given pharmacological treatment, but the available …

Introduction: Intra-articular (IA) drug delivery is very useful in the treatment of osteoarthritis
(OA), the most common chronic joint affliction. However, the therapeutic effect of IA …

Highlights•Precision medicine is necessary to treat multiple facets of osteoarthritis.•Disease-
modifying osteoarthritis drugs (DMOADs) and drug delivery systems (DDSs) are …

Osteoarthritis (OA) is a primarily non-inflammatory, degenerative joint disease characterized
by progressive loss of articular cartilage, subchondral bone sclerosis, osteophyte formation …

Osteoarthritis (OA) is a progressive and degenerative disease, which is no longer confined
to the elderly. So far, current treatments are limited to symptom relief, and no valid OA …

Osteoarthritis (OA） is a common orthopaedic disease in middle-aged and aged people. To
date, no disease-modifying drug is available to prevent the progression of OA. Surgical …

Osteoarthritis (OA) is a joint degenerative disease that has become one of the leading
causes of disability in the world. It is estimated that OA affects 50 million adults in the United …

To date, no targeted treatments for osteoarthritis have been developed. Therefore the
challenge for the next years is to find a treatment that may slow down the progression of the …

Introduction: Osteoarthritis (OA) is the leading cause of disability in the elderly, usually
presenting with mono-or oligo-arthritis where local drug delivery by intra-articular (IA) …

Highlights•Focus on disease-modifying approaches for intra-articular drug
delivery.•Polymeric particles as platforms for sustained and controlled drug release.•In vivo …