Fungal species have dynamic genomes and often exhibit genomic plasticity in response to
stress. This genome plasticity often comes with phenotypic consequences that affect fitness …

Rapid responses to acute stresses are essential for stress survival and are critical to the
ability of fungal pathogens to adapt to new environments or hosts. The rapid emergence of …

The ability of an organism to replicate and segregate its genome with high fidelity is vital to
its survival and for the production of future generations. Errors in either of these steps …

Aneuploidy, a deviation from a balanced genome by either gain or loss of chromosomes, is
generally associated with impaired fitness and developmental defects in eukaryotic …

Diversity within the fungal kingdom is evident from the wide range of morphologies fungi
display as well as the various ecological roles and industrial purposes they serve …

Human fungal pathogens can exist in a variety of ploidy states, including euploid and
aneuploid forms. Ploidy change has a major impact on phenotypic properties, including the …

Genome sequencing of fungal pathogens have documented extensive variation in genome
structure and composition between species and in many cases between individuals of the …

Organismal ploidy and environmental stress impact the rates and types of mutational events.
The opportunistic fungal pathogen Candida albicans, serves as a clinically relevant model …

Changes in ploidy have a profound and usually negative influence on cellular viability and
proliferation, yet the vast majority of cancers and tumours exhibit an aneuploid karyotype …

Fungal pathogens pose an increasingly worrying threat to human health, food security and
ecosystem diversity. To tackle fungal infections and improve current diagnostic and …